Neuroendocrine and immune relationships in postpartum fatigue.
Neuroendocrine and immune relationships in postpartum fatigue.
复制标题
产后疲劳的神经内分泌和免疫关系。
DOI：
10.1097/00005721-200503000-00012
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Groër,Sean
中科院分区：
文献类型：
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作者：
Groër,Maureen;Davis,Mitzi;Casey,Karyn;Short,Blair;Smith,Kathlene;Groër,Sean
目的：探讨产后疲劳、抑郁、压力与感染的关系。研究设计和方法：这是一项横断面的相关设计，样本为119名产后4至6周的新妈妈。母亲们完成了疲劳、情绪和压力测试以及母婴感染检查表。采集母乳喂养者的晨血和后乳样本。ELISA法测定催乳素、皮质醇、褪黑素和分泌IgA （sIgA）。探讨了社会心理、健康和生物变量之间的相关性。结果：疲劳与母亲和婴儿的感染症状、感知压力和产后压力以及抑郁相关。血清催乳素与抑郁呈负相关。牛奶sIgA与催乳素相关，与应激负相关。牛奶褪黑素与催乳素呈负相关，疲劳评分与褪黑素呈负相关，与催乳素呈负相关。临床意义：数据表明，疲劳、压力、抑郁和感染与产后母亲有关，这些关系延伸到血清激素和乳因子水平。有可能形成一种循环，当母亲感到压力时，疲劳的影响成倍增加，这种压力和疲劳的循环可能导致免疫缺陷和传染病。
Purpose:To explore relationships between fatigue, depression, stress, and infection in the postpartum.Study Design and Methods:This was a cross-sectional, correlational design with a sample of 119 new mothers at 4 to 6 weeks postpartum. Mothers completed fatigue, mood, and stress instruments as well as maternal and infant infection checklists. Morning blood and hindmilk (in breastfeeders) samples were collected. ELISA was used to measure prolactin, cortisol, melatonin, and secretory IgA (sIgA). Correlations between psychosocial, health, and biologic variables were explored.Results:Fatigue was correlated with symptoms of infection in both mothers and babies, with perceived stress and postpartum stress as well as with depression. Serum prolactin was inversely associated with depression. Milk sIgA was related to milk prolactin and inversely related to stress. Milk melatonin and prolactin were inversely related, and fatigue scores were correlated with melatonin and inversely with prolactin.Clinical Implications:The data suggest that fatigue, stress, depression, and infection are related in postpartum mothers and that these relationships extend to levels of serum hormones and milk factors. It is possible that a cycle is established that multiplies the effects of fatigue when mothers experience stress and that this cycle of stress and fatigue may lead to immune deficits and infectious illnesses.