Neutrophil-Epithelial Interactions A Double-Edged Sword
Neutrophil-Epithelial Interactions A Double-Edged Sword
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DOI：
10.1016/j.ajpath.2016.02.001
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发表时间：
2016-06-01
影响因子：
6
通讯作者：
Parkos, Charles A.
中科院分区：
文献类型：
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作者：
Parkos, Charles A.
近年来，一种被称为中性粒细胞的先天免疫细胞显然是一把双刃剑，它们在清除感染方面发挥着关键作用，但也会造成组织损伤，同时对伤口愈合也至关重要。中性粒细胞向受伤组织或感染部位的募集已得到充分研究，许多调节白细胞从微循环渗出的分子事件现在也已被了解。然而，在离开循环系统后，调节中性粒细胞到达诸如黏膜表面等最终靶点的分子细节才刚刚开始被认识到。鉴于中性粒细胞穿过黏膜上皮的迁移与疾病症状以及诸如炎症性肠病等疾病中关键屏障功能的破坏有关，长期以来人们一直对理解中性粒细胞 - 上皮相互作用的分子基础和功能后果感兴趣。去年我的工作获得了劳斯 - 惠普尔奖，这是极大的荣幸，使我有机会总结我们在过去几十年中对白细胞与上皮细胞相互作用所了解的情况。
In recent years, it has become clear that innate immune cells termed neutrophils act as double-edged swords by playing essential roles in clearing infection but also causing tissue damage, yet being critical for wound healing. Neutrophil recruitment to sites of injured tissue or infection has been well studied, and many of the molecular events that regulate passage of leukocytes out of the microcirculation are now understood. However, after exiting the circulation, the molecular details that regulate neutrophil passage to end targets, such mucosal surfaces, are just beginning to be appreciated. Given that migration of neutrophils across m ucosal epithelia is associated with disease symptoms and disruption of critical barrier function in disorders such as inflammatory bowel disease, there has been long-standing interest in understanding the molecular basis and functional consequences of neutrophil-epithelial interactions. It is a great honor that my work was recognized by the Rous-Whipple Award this past year, giving me the opportunity to summarize what we have learned during the past few decades about leukocyte interactions with epithelial cells.