Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli.
Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli.
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单链 DNA 结合蛋白可增强大肠杆菌中 CTG 三联体重复序列的稳定性。
DOI：
10.1128/jb.178.16.5042-5044.1996
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发表时间：
1996
影响因子：
3.2
通讯作者：
Sinden,RR
中科院分区：
文献类型：
--
作者：
Rosche,WA;Jaworski,A;Kang,S;Kramer,SF;Larson,JE;Geidroc,DP;Wells,RD;Sinden,RR
在大肠杆菌中分析CTG三联重复序列的稳定性，以确定导致其遗传不稳定性的过程。使用生化测定的稳定性，我们表明，单链DNA结合蛋白的情况下，导致增加的频率内的三重重复大的缺失。
The stability of CTG triplet repeats was analyzed in Escherichia coli to identify processes responsible for their genetic instability. Using a biochemical assay for stability, we show that the absence of single-stranded-DNA-binding protein leads to an increase in the frequency of large deletions within the triplet repeats.