Bifidobacterium longum subsp. longumOLP-01 Supplementation during Endurance Running Training Improves Exercise Performance in Middle- and Long-Distance Runners: A Double-Blind Controlled Trial
Bifidobacterium longum subsp. longumOLP-01 Supplementation during Endurance Running Training Improves Exercise Performance in Middle- and Long-Distance Runners: A Double-Blind Controlled Trial
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DOI：
10.3390/nu12071972
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发表时间：
2020-07-01
期刊：
影响因子：
5.9
通讯作者：
Lee, Mon-Chien
中科院分区：
文献类型：
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作者：
Lin, Che-Li;Hsu, Yi-Ju;Lee, Mon-Chien
长双歧杆菌longumOlympic No.1（OLP-01）在先前的动物实验中已显示出改善运动耐力表现，但这种效果尚未在人类中或更具体地在运动员中得到证实。为此，目前的研究将OLP-01补充剂与国立台湾体育大学训练有素的中长跑运动员的定期运动训练相结合。该研究被设计为双盲安慰剂对照实验。根据12分钟内行驶的总距离（米），将21名受试者（14名男性和7名女性，年龄20-30岁）均匀分配至以下两组之一：安慰剂组（7名男性和3名女性）和OLP-01（1.5 x 10（10）菌落形成单位（CFU）/天）组（7名男性和4名女性）。所有参与者连续五周接受安慰剂或OLP-01补充剂，包括三周的常规训练和两周的停训。在实验前后，参与者进行了12分钟的跑步/步行距离测试，并分析了身体成分，血液/血清和粪便样本。结果表明，OLP-01显著增加了12分钟库珀测试跑距离和肠道菌群丰度的变化。虽然没有发现身体成分的显着变化，但OLP-01对参与者的身体没有造成不良反应或伤害。综上所述，OLP-01可作为运动营养补充剂，特别是运动员，以提高运动成绩。
Bifidobacterium longum subsp. longumOlympic No. 1 (OLP-01) has been shown in previous animal experiments to improve exercise endurance performance, but this effect has not been confirmed in humans, or more particularly, in athletes. Toward this end, the current study combined OLP-01 supplementation with regular exercise training in well-trained middle- and long-distance runners at the National Taiwan Sport University. The study was designed as a double-blind placebo-controlled experiment. Twenty-one subjects (14 males and seven females aged 20-30 years) were evenly distributed according to total distance (meters) traveled in 12 min to one of the following two groups: a placebo group (seven males and three females) and an OLP-01 (1.5 x 10(10)colony forming units (CFU)/day) group (seven males and four females). All the participants received placebo or OLP-01 supplements for five consecutive weeks consisting of three weeks of regular training and two weeks of de-training. Before and after the experiment, the participants were tested for 12-min running/walking distance, and body composition, blood/serum, and fecal samples were analyzed. The results showed that OLP-01 significantly increased the change in the 12-min Cooper's test running distance and the abundance of gut microbiota. Although no significant change in body composition was found, OLP-01 caused no adverse reactions or harm to the participants' bodies. In summary, OLP-01 can be used as a sports nutrition supplement, especially for athletes, to improve exercise performance.