Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog
Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog
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DOI：
10.1101/gad.10.3.301
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发表时间：
1996-02-01
影响因子：
10.5
通讯作者：
Scott, MP
中科院分区：
文献类型：
--
作者：
Goodrich, LV;Johnson, RL;Scott, MP
信号蛋白 Hedgehog (Hh) 控制果蝇和脊椎动物的细胞命运并极化组织。在果蝇中，Hh 通过对抗新型跨膜蛋白 Patched 的功能来发挥作用，同时还局部诱导 patched (ptc) 转录。我们已经鉴定出 ptc 的小鼠同源物，它在许多组织中在形成 Sonic 或 Indian humility 的细胞附近转录。此外，小鼠中枢神经系统中的异位Sonic Hedgehog表达诱导ptc转录。与果蝇一样，小鼠 ptc 转录似乎表明 Hedgehog 信号接收。结果支持昆虫和哺乳动物中存在用于模式形成的保守信号通路。
The signaling protein Hedgehog (Hh) controls cell fate and polarizes tissues in both flies and vertebrates. In flies, Hh exerts its effects by opposing the function of a novel transmembrane protein, Patched, while also locally inducing patched (ptc) transcription. We have identified a mouse homolog of ptc which in many tissues is transcribed near cells making either Sonic or Indian hedgehog. In addition, ectopic Sonic hedgehog expression in the mouse central nervous system induces ptc transcription. As in flies, mouse ptc transcription appears to be indicative of Hedgehog signal reception. The results support the existence of a conserved signaling pathway used for pattern formation in insects and mammals.