Fiber-tracking techniques can predict the degree of neurologic impairment for periventricular leukomalacia
Fiber-tracking techniques can predict the degree of neurologic impairment for periventricular leukomalacia
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DOI：
10.1542/peds.2007-2816
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发表时间：
2008-09-01
期刊：
影响因子：
8
通讯作者：
Sugimoto, Tohru
中科院分区：
文献类型：
--
作者：
Murakami, Aki;Morimoto, Masafumi;Sugimoto, Tohru
目标。早产儿或低出生体重儿在围产期表现出更大的由缺氧缺血性脑病引起的白质损伤倾向。这种发作可导致脑室周围白质软化，这可能会严重影响后来的大脑发育。在生命早期评估损伤严重程度的无创方法尚未建立。我们使用弥散张量成像评估感觉运动纤维在脑室周围白质软化。对10例脑室周围白质软化患者进行了兴趣区测量和基于神经束造影的测量。患者平均年龄19±9.5个月（范围：9 ~ 41个月）。运动功能在平均年龄28 +/- 14.5个月时进行评估。所有轻度脑室周围白质软化病例的运动道测量分数各向异性值明显高于严重病例。的分数各向异性截止值
OBJECTIVE. Preterm or low birth weight infants display a greater propensity for white matter injury caused by hypoxic-ischemic encephalopathy in the perinatal period. Such episodes can result in periventricular leukomalacia, which may substantially influence later brain development. Noninvasive methods of assessing the severity of injury at the earliest stage of life have not yet been established.METHODS. We used diffusion tensor imaging to evaluate sensorimotor fibers in periventricular leukomalacia. Region-of-interest measurements and tractography-based measurements were performed for 10 patients with periventricular leukomalacia. The mean age of the patients was 19 +/- 9.5 months (range: 9-41 months). Motor functions were assessed at a mean age of 28 +/- 14.5 months.RESULTS. Measured fractional anisotropy values of the motor tract were significantly higher in all mild periventricular leukomalacia cases than in severe cases. A fractional anisotropy cutoff value of