Frequency of TLR 2, 4, and 9 gene polymorphisms in Chinese population and their susceptibility to type 2 diabetes and coronary artery disease.
Frequency of TLR 2, 4, and 9 gene polymorphisms in Chinese population and their susceptibility to type 2 diabetes and coronary artery disease.
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DOI：
10.1155/2012/373945
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发表时间：
2012
影响因子：
--
通讯作者：
Feng B
中科院分区：
文献类型：
--
作者：
Liu F;Lu W;Qian Q;Qi W;Hu J;Feng B
Toll样受体（TLR）是先天免疫应答的关键组分。先天免疫系统的激活和随后的慢性低度炎症被认为参与动脉粥样硬化和2型糖尿病的发病机制。在本研究中，我们对TLRs基因多态性进行了分型，包括TLR 2 Arg 677 Trp和Arg 753 Gln，TLR 4 Asp 299 Gly和Thr 399 Ile，TLR 9 - 1486 T/C和-1237T/C。TLR 9 - 1486 T/C突变的TT、TC和CC基因型频率分别为39.6%、45.8%和14.6%，T等位基因和C等位基因频率分别为62.5%和37.5%。然而，这些参数在研究组中均不具有统计学显著性。此外，我们惊讶地发现，在西方国家常见的TLR SNPs，如TLR 2 Arg 677 Trp或Arg 753 Gln，TLR 4 Asp 299 Gly或Thr 399 Ile和TLR 9 - 1237 T/C，在所有研究对象中完全没有多态性。结论：TLR 2 Arg 677 Trp或Arg 753 Gln、TLR 4 Asp 299 Gly或Thr 399 Ile和TLR 9 - 1237 T/C多态性在中国汉族人群中的频率较低，TLR 9 - 1486 T/C多态性可能不是预测2型糖尿病或冠心病易感性的合适标记。
Toll-like receptors (TLRs) are pivotal components of the innate immune response. Activation of the innate immune system and subsequent chronic low-grade inflammation are thought to be involved in the pathogenesis of atherosclerosis and type 2 diabetes. In the study, we genotyped TLRs gene polymorphisms, including TLR2 Arg677Trp and Arg753Gln, TLR4 Asp299Gly and Thr399Ile, TLR9-1486T/C and -1237T/C. The frequencies of TT, TC and CC genotype of TLR9-1486T/C mutation were 39.6%, 45.8% and 14.6%, respectively; the frequencies of T allele and C allele were 62.5% and 37.5%. However, neither of these parameters was statistically significant among study groups. In addition, we were surprised to find that the commonly reported TLR SNPs in the Western countries, like TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gly or Thr399Ile and TLR9-1237T/C, were not polymorphic at all in all study subjects. In conclusion, our data suggests that TLR2 Arg677Trp or Arg753Gln, TLR4 Asp299Gly or Thr399Ile and TLR9-1237T/C polymorphisms have low frequency and TLR9-1486T/C polymorphism may not be a suitable marker in predicting the susceptibility to type 2 diabetes or coronary artery disease in the Chinese Han population.
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