Local minocycline as an adjunct to surgical therapy in moderate to severe, chronic periodontitis.
Local minocycline as an adjunct to surgical therapy in moderate to severe, chronic periodontitis.
复制标题
局部米诺环素作为中度至重度慢性牙周炎手术治疗的辅助药物。
DOI：
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发表时间：
2008
影响因子：
6.7
通讯作者：
P. Ramberg
中科院分区：
文献类型：
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作者：
M. Hellström;P. McClain;R. Schallhorn;Lynn Bellis;A. Hanlon;P. Ramberg
目的
本研究的目的是评估米诺环素微球与手术联合使用时对中度至重度慢性牙周炎成人牙周探诊深度减少的影响。
材料和方法
60名患者在两个口腔象限中至少有一个非磨牙牙周部位≥ 6 mm，在基线时、两种手术治疗后立即（第2周和第3周）和第5周或单独手术时接受局部米诺环素微球。
结果
第25周时，试验组和对照组中基线>或=5 mm部位的平均探测深度减少分别为2.51 mm和2.18 mm。测试组吸烟者的探测深度减少（2.30 mm）显著大于对照组吸烟者（2.05 mm）。试验组中探测深度减少>或=2 mm和>或=3 mm的部位数量显著高于对照组。
结论
在患有中度至重度慢性牙周炎的成年人中，局部应用米诺环素作为手术辅助治疗，与单独手术相比，在统计学上显著降低了探查深度。
OBJECTIVE
The aim of the study was to evaluate the effects of minocycline microspheres on periodontal probing depth reduction when used in combination with surgery in adults with moderate to severe, chronic periodontitis.
MATERIAL AND METHODS
Sixty patients with a minimum of one non-molar periodontal site > or =6 mm in two oral quadrants received either local minocycline microspheres at baseline, immediately following each of two surgical therapies (Weeks 2 and 3), and at Week 5 or surgery alone.
RESULTS
The mean probing depth reduction at Week 25 at sites > or =5 mm at baseline was 2.51 mm in the test group and 2.18 mm in the control group. Smokers in the test group had a significantly greater probing depth reduction (2.30 mm) than smokers in the control group (2.05 mm). The number of sites with probing depth reductions of > or =2 and > or =3 mm were significantly higher in the test group than in the control group.
CONCLUSION
Applications of local minocycline as an adjunct to surgery in adults with moderate to severe, chronic periodontitis were associated with statistically significant greater reductions in probing depth than surgery alone.