DNA damage response and repair data with pharmacological modulators of Tousled.
DNA damage response and repair data with pharmacological modulators of Tousled.
复制标题
使用 Tousled 药理调节剂的 DNA 损伤反应和修复数据。
DOI：
10.1016/j.dib.2016.03.075
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发表时间：
2016
期刊：
影响因子：
1.2
通讯作者：
Sunavala-Dossabhoy,Gulshan
中科院分区：
文献类型：
--
作者：
TimiriShanmugam,PrakashSrinivasan;Nair,RenjithP;DeBenedetti,Arrigo;Caldito,Gloria;Abreo,Fleurette;Sunavala-Dossabhoy,Gulshan
人类Tousled激酶1（TLK1）在染色质重塑、复制和DNA损伤反应和修复中起重要作用。TLK1活性在遗传毒性损伤后立即但短暂地下调，并且其恢复对于放射后从检查点停滞和细胞存活中退出是重要的。本文中的数据补充了题为“Tousled kinase activator，gallic acid，promotes DNA repair and suppresses radiation cytotoxicity in salivary gland cells”的论文中提出的研究[1]。TLK1小分子激活剂和抑制剂的鉴定为进一步改变蛋白质的活性以阐明其在DNA损伤反应途径中的作用提供了机会。TLK1效应子，没食子酸（GA）和硫利达嗪（THD）分别激活和抑制激酶，数据报告了这些化合物的影响以及TLK1对DNA断裂修复和人唾液腺泡细胞存活的意义。
Human Tousled kinase 1 (TLK1) plays an important role in chromatin remodeling, replication, and DNA damage response and repair. TLK1 activity is immediately, but transiently, downregulated after genotoxic insult, and its recovery is important for exit from checkpoint arrest and cell survival after radiation. The data in this article compliments research presented in the paper titled, “Tousled kinase activator, gallic acid, promotes DNA repair and suppresses radiation cytotoxicity in salivary gland cells” [1]. The identification of small molecule activators and inhibitors of TLK1 provided an opportunity to pharmacologically alter the protein׳s activity to elucidate its role in DNA damage response pathways. TLK1 effectors, gallic acid (GA) and thioridazine (THD) activate and inhibit the kinase, respectively, and the data report on the impact of these compounds and the significance of TLK1 to DNA break repair and the survival of human salivary acinar cells.