FURTHER INVESTIGATIONS ON MODE OF ENTRY OF VACCINIA VIRUS INTO CELLS
FURTHER INVESTIGATIONS ON MODE OF ENTRY OF VACCINIA VIRUS INTO CELLS
复制标题
DOI：
10.1099/0022-1317-32-2-275
复制
发表时间：
1976-01-01
影响因子：
3.8
通讯作者：
METZ, DH
中科院分区：
文献类型：
--
作者：
CHANG, A;METZ, DH
早期的结果表明，牛痘病毒进入[小鼠成纤维细胞] L细胞的病毒包膜和细胞质膜之间的直接融合的过程得到证实，并使用免疫铁蛋白缀合物定位病毒抗原在宿主细胞表面上扩展。融合后，病毒包膜的组分迅速分散在质膜中。还观察到融合作为牛痘病毒进入HeLa细胞的主要模式。
Earlier results indicating that vaccinia virus entered [mouse fibroblast] L cells by a process of direct fusion between the virus envelope and the plasma membrane of the cell were confirmed and extended using immuno-ferritin conjugates to locate virus antigens on the host cell surface. After fusion, components of the virus envelope become rapidly dispersed in the plasma membrane. Fusion was also observed as the predominant mode of entry of vaccinia virus into HeLa cells.