ABNORMAL GOBLET CELL GLYCOCONJUGATES IN RECTAL BIOPSIES ASSOCIATED WITH AN INCREASED RISK OF NEOPLASIA IN PATIENTS WITH ULCERATIVE-COLITIS - EARLY RESULTS OF A PROSPECTIVE-STUDY
ABNORMAL GOBLET CELL GLYCOCONJUGATES IN RECTAL BIOPSIES ASSOCIATED WITH AN INCREASED RISK OF NEOPLASIA IN PATIENTS WITH ULCERATIVE-COLITIS - EARLY RESULTS OF A PROSPECTIVE-STUDY
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DOI：
10.1136/gut.25.12.1364
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发表时间：
1984-01-01
期刊：
影响因子：
24.5
通讯作者：
KIM, YS
中科院分区：
文献类型：
--
作者：
BOLAND, CR;LANCE, P;KIM, YS
整个结肠至少8年的稳定型溃疡性结肠炎患者（18例）接受了外观正常的直肠粘膜活检，并前瞻性随访4年以上，以确定是否发生异型增生或癌症。在直肠活检中使用荧光素结合凝集素检查杯状细胞糖缀合物结构。在研究开始时，18例患者中有13例在直肠活检中出现杯状细胞粘蛋白或胞浆糖缀合物异常。其中6例发生异型增生，1例发生癌。在最初的直肠活检中凝集素结合研究正常的5例患者中，1例随后发展为结肠发育不良。在直肠杯状细胞中观察到的异常部分类似于在未成熟和肿瘤性结肠细胞中观察到的异常。这些不典型增生的组织都含有结肠肿瘤组织中发现的粘蛋白。慢性溃疡性结肠炎的糖缀合物结构异常可能与肿瘤事件有关，也可能先于肿瘤事件。
Patients (18) with stable ulcerative colitis of the entire colon for at least 8 yr were subjected to a biopsy of normal appearing rectal mucosa and followed prospectively over 4 yr for the development of dysplasia or cancer. Goblet cell glycoconjugate structure was examined in the rectal biopsies using fluorescein conjugated lectins. At the beginning of the study, 13 of the 18 patients had abnormalities of goblet cell mucin or cytoplasmic glycoconjugates in the rectal biopsies. Dysplasia subsequently developed in 6 and carcinoma in 1 of these patients. Among the 5 patients with normal lectin binding studies in the initial rectal biopsies, colonic dysplasia has subsequently developed in one. The abnormalities seen in the rectal goblet cells resembled in part those seen in immature and neoplastic colonic cells. The dysplastic tissue all contained the form of mucin which has been found in neoplastic colonic tissues. With chronic ulcerative colitis abnormalities of glycoconjugate structure may be associated with, and may precede, neoplastic events.