Epicardial Fat Volume in Patients With Left Ventricular Systolic Dysfunction
Epicardial Fat Volume in Patients With Left Ventricular Systolic Dysfunction
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DOI：
10.1016/j.amjcard.2011.03.058
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发表时间：
2011-08-01
影响因子：
2.8
通讯作者：
Schulze, P. Christian
中科院分区：
文献类型：
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作者：
Khawaja, Tuba;Greer, Christine;Schulze, P. Christian
心外膜脂肪组织与心血管代谢和炎症有关，并已被证明可以预测冠状动脉疾病的患病率和进展。关于心外膜脂肪在心力衰竭（HF）患者中的作用的数据有限。我们分析了左心室（LV）功能正常和受损患者的心脏肥胖及其与发病标志物和临床结果的关系。研究人员测量了 381 名接受低剂量计算机断层扫描的患者（210 名女性和 171 名男性，平均年龄 55 +/- 10 岁）的心外膜脂肪体积 (EFV) 和冠状动脉钙。心力衰竭的定义是左心室射血分数 (EF) 55%（平均 63 +/- 6），60 名患者有 EF
Epicardial adipose tissue has been linked to cardiovascular metabolism and inflammation and has been shown to predict prevalence and progression of coronary artery disease. Only limited data are available on the role of epicardial fat in patients with heart failure (HF). We analyzed cardiac adiposity and its relation to markers of morbidity and clinical outcome in patients with normal and impaired left ventricular (LV) function. Epicardial fat volume (EFV) and coronary artery calcium were measured in 381 patients (210 women and 171 men, mean age 55 +/- 10 years) who underwent low-dose computed tomography. HF was defined by LV ejection fraction (EF) 55% (mean 63 +/- 6) and 60 patients had an EF