Preparation and retention behaviour of chemically bonded methylated-cyclodextrin stationary phases for liquid chromatography
Preparation and retention behaviour of chemically bonded methylated-cyclodextrin stationary phases for liquid chromatography
复制标题
化学键合甲基化环糊精液相色谱固定相的制备及保留行为
DOI：
10.1016/s0021-9673(01)97733-7
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发表时间：
1984
影响因子：
4.1
通讯作者：
T. Shono
中科院分区：
文献类型：
--
作者：
M. Tanaka;Y. Kawaguchi;Takashi Niinae;T. Shono
α-环糊精和β-环糊精均转化为乙二胺单取代的对o -甲基衍生物，后者与琥珀酰胺丙基二氧化硅偶联。与未修饰的α-环糊精固定相相比，甲基化的α-环糊精固定相改善了几种二取代苯衍生物的理论、中间和对异构体的分离。而β-环糊精的甲基化对三种异构体的分离选择性较差。甲基化β-环糊精固定相能有效分离抗癫痫药物或取代萘衍生物。
Both α-and β-cyclodextrinwere converted into the ethylenediamine monosubstituted per-O-methyl derivatives, and the latter were coupled to succinamidopropyl silica. The resulting methylated α-cyclodextrinstationary phase improves the separation of theortho,metaandparaisomers of several disubstituted benzene derivatives, compared with the unmodified α-cyclodextrin stationary phase. Methylation of β-cyclodextrin, however, results in less good selectivity in the separation of the three isomers. The methylated β-cyclodextrin stationary phase can efficiently separate the antiepileptic drugs or the substituted naphthalene derivatives.