VASOACTIVE INTESTINAL POLYPEPTIDE (VIP) IMMUNOREACTIVE ELEMENTS IN THE CAUDAL VENTRAL STRIATUM OF THE RAT - A LIGHT AND ELECTRON-MICROSCOPIC STUDY
VASOACTIVE INTESTINAL POLYPEPTIDE (VIP) IMMUNOREACTIVE ELEMENTS IN THE CAUDAL VENTRAL STRIATUM OF THE RAT - A LIGHT AND ELECTRON-MICROSCOPIC STUDY
复制标题
DOI：
10.1016/0361-9230(91)90262-i
复制
发表时间：
1991-06-01
影响因子：
3.8
通讯作者：
TIAN, Q
中科院分区：
文献类型：
--
作者：
CHANG, HT;TIAN, Q
在前连合的后肢下方，腹侧纹状体和腹侧苍白球之间的一个大脑区域先前被de Olmos确定为前连合后肢的间质核（7）。该区域，这里称为尾侧腹侧纹状体（VSC），其特征在于血管活性肠肽免疫反应（VIP +）轴突的密集丛。双荧光免疫细胞化学反应揭示了在也富含多巴胺能的区域中发现了致密的VIP+丛（即，酪氨酸羟化酶免疫反应阳性纤维，但缺乏脑啡肽能终末。VSc内VIP+轴突的密集丛与终纹床核（BNST）和杏仁中央核（CNA）内的VIP+轴突的密集丛相邻。这些结果支持了这一观点，即该VSC区域是Alheid和Heimer最近提出的“延伸杏仁核”的一部分（2），并证实其解剖学特性与腹侧纹状体的关系比腹侧苍白球更密切。电镜分析显示VIP+终扣与树突和棘形成不对称突触，与未标记的VSc神经元胞体形成对称突触。该区域内的少数VIP+神经元与它们的胞体和树突上的许多未标记的轴突终末形成突触。然而，一些VIP+神经元也与VIP+终扣形成轴体和轴树突触。
Under the posterior limb of the anterior commissure, a brain region intercalated between the ventral striatum and the ventral pallidum was previously identified as the interstitial nucleus of the posterior limb of the anterior commissure by de Olmos (7). This region, referred here as the caudal ventral striatum (VSc), is characterized by a dense plexus of vasoactive intestinal peptide immunoreactive (VIP +) axons. Double-fluorescence immunocytochemical reactions reveal that the dense VIP+ plexus is found in a region also rich in dopaminergic (i.e., tyrosine-hydroxylase immunoreactive) fibers but poor in enkephalinergic terminals. The dense plexuses of VIP+ axons in VSc appear to be contiguous with those in the bed nucleus of stria terminalis (BNST) and the central nucleus of amygdala (CNA). These results support the notion that this VSc region is a part of the "extended amygdala" as proposed recently by Alheid and Heimer (2), and confirms that its anatomical properties are closer related to the ventral striatum than the ventral pallidum. Electron microscopic analysis reveals that the VIP+ boutons form asymmetrical synapses with dendrites and spines, and symmetrical synapses with somata of unlabeled VSc neurons. The few VIP+ neurons within this area form synapses with many unlabeled axon terminals on both their somata and dendrites. Some VIP+ neurons, however, also form axosomatic and axodendritic synapses with VIP+ boutons.