Successful cord blood transplantation for myelodysplastic syndrome complicated by Mycobacterium kansasii pneumonia
Successful cord blood transplantation for myelodysplastic syndrome complicated by Mycobacterium kansasii pneumonia
复制标题
脐带血移植成功治疗骨髓增生异常综合征并发堪萨斯分枝杆菌肺炎
DOI：
10.1111/tid.13463
复制
发表时间：
2020
影响因子：
2.6
通讯作者：
Gotoh Akihiko
中科院分区：
文献类型：
--
作者：
Yamada Arisa;Akahane Daigo;Katagiri Seiichiro;Yoshizawa Seiichiro;Furuya Nahoko;Fujimoto Hiroaki;Gotoh Moritaka;Gotoh Akihiko
非结核分枝杆菌(NTM)病是血液系统恶性肿瘤患者中性粒细胞减少性发热的罕见原因。对于这类NTM患者的最佳治疗方法的研究很少。我们报告一例肺炎后进行脐带血移植治疗骨髓增生异常综合征(MDS)的病例。一名38岁男子被诊断为MDS，在诱导化疗期间发展为严重肺炎。反复痰培养发现有分枝杆菌感染。然后，通过对支气管灌洗液进行聚合酶链式反应，证实了堪萨斯支原体感染。经过140天的抗NTM治疗，CBT成功实施，患者康复，无NTM感染复发。此病例提供了有价值的证据，表明在可靠的诊断和持续的抗NTM治疗后，造血干细胞移植是可行的。
Non‐tuberculous mycobacterial (NTM) disease is a rare cause of neutropenic fever in patients with hematological malignancies. There are few studies on the optimal management for such patients with NTM. We report a case of myelodysplastic syndrome (MDS) treated by umbilical cord blood transplantation (CBT) afterMycobacterium kansasii(M kansasii) pneumonia. A 38‐year‐old man diagnosed with MDS developed severe pneumonia during induction chemotherapy. Repeated sputum culture uncovered mycobacterium infection. Then, by the polymerase chain reaction of the bronchial lavage fluid,M kansasiiinfection was proven. After 140 days of anti‐NTM therapy, CBT was successfully carried out and the patient recovered without recurrence of NTM infection. This case provides valuable evidence that hematopoietic stem cell transplantation is feasible after a reliable diagnosis and continuous anti‐NTM therapy.