A longitudinal study of gait function and characteristics of gait disturbance in individuals with Alzheimer's disease
A longitudinal study of gait function and characteristics of gait disturbance in individuals with Alzheimer's disease
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DOI：
10.1016/j.gaitpost.2013.12.026
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发表时间：
2014-04-01
期刊：
影响因子：
2.4
通讯作者：
Aberg, Anna Cristina
中科院分区：
文献类型：
--
作者：
Cedervall, Ylva;Halvorsen, Kjartan;Aberg, Anna Cristina
日常生活中的行走对认知和运动功能之间的相互作用提出了很高的要求。因此，良好的双重任务处理能力对于安全行走至关重要。研究的目的是在两年的时间里研究最初轻度AD患者(n=21)在单任务和双任务过程中步态功能的纵向变化。数据被收集了三次，相隔12个月。使用光学运动捕捉系统进行三维步态分析。在单任务、双任务命名名字和命名动物的过程中，以舒适的步态速度检查步态参数。步态速度的双重任务成本在基线时显著(名字为26%，动物为35%)，并在研究期间保持不变。在单任务和双任务中，步态速度和步长有显著的纵向下降(p<；0.05)，而双支撑时间、步宽和步高显示出不一致的结果。对运动捕捉文件的系统视觉检查显示，双重任务经常导致步态干扰。确定了此类扰动的三个主要特征：时间扰动、空间扰动和单一姿态下的不稳定性。这些异常的步态表现可能会影响步态的稳定性，并增加摔倒的风险。此外，观察到的步态干扰有助于理解和解释先前报道的阿尔茨海默病患者的步态差异。然而，双重任务测试和异常的双重任务步态表现在识别有认知损害早期迹象的个体和预测AD跌倒风险方面的作用仍有待研究。(C)2014年提交人。爱思唯尔出版，版权所有。
Walking in daily life places high demands on the interplay between cognitive and motor functions. A well-functioning dual-tasking ability is thus essential for walking safely. The aims were to study longitudinal changes in gait function during single-and dual-tasking over a period of two years among people with initially mild AD (n = 21). Data were collected on three occasions, twelve months apart. An optical motion capture system was used for three-dimensional gait analysis. Gait parameters were examined at comfortable gait speed during single-tasking, dual-tasking naming names, and naming animals. The dual-task cost for gait speed was pronounced at baseline (names 26%, animals 35%), and remained so during the study period. A significant ( p < 0.05) longitudinal decline in gait speed and step length during single- and dual-tasking was observed, whereas double support time, step width and step height showed inconsistent results. Systematic visual examination of the motion capture files revealed that dual-tasking frequently resulted in gait disturbances. Three main characteristics of such disturbances were identified: Temporal disturbance, Spatial disturbance and Instability in single stance. These aberrant gait performances may affect gait stability and increase the risk of falling. Furthermore, the observed gait disturbances can contribute to understanding and explaining previous reported gait variability among individuals with AD. However, the role that dual-task testing and aberrant dual-task gait performance play in the identification of individuals with early signs of cognitive impairment and in predicting fall risk in AD remains to be studied. (c) 2014 The Authors. Published by Elsevier B.V. All rights reserved.