Familial breast and ovarian cancer:: A Swedish population-based register study
Familial breast and ovarian cancer:: A Swedish population-based register study
复制标题
DOI：
10.1093/aje/152.12.1154
复制
发表时间：
2000-12-15
影响因子：
5
通讯作者：
Möller, TR
中科院分区：
文献类型：
--
作者：
Anderson, H;Bladström, A;Möller, TR
1958-1993年被诊断患有乳腺癌或卵巢癌的母亲的后代队列是使用瑞典基于人口的登记建立的。这些儿童(n=158,041)出生于1941年至1993年之间，并跟踪了他们在1961年至1993年之间的癌症发病率。总共发现了3102名儿童的3257个肿瘤。观察到的病例数量与基于国家历年、年龄和性别特定发病率的预期数量进行了比较。对于女性乳腺癌患者的女儿，50岁前被诊断为乳腺癌和卵巢癌的标化发病率比分别为1.99(95%可信区间：1.86，2.14)和1.28(95%可信区间：1.05，1.54)。卵巢癌患者女儿的相应数字分别为1.79(95%CI：1.55，2.07)和2.38(95%CI：1.77，3.12)。如果母亲在很小的时候就被诊断出患有癌症，母亲有多种乳房/卵巢疾病诊断，或者有一个患有乳腺癌/卵巢癌的姐妹，风险就会增加。在所有子女中，发现患甲状腺癌、睾丸癌和恶性黑色素瘤的风险增加，而如果母亲患有乳腺癌，患肺癌的风险降低。作者开发了标准化发病率的方差估计器，以处理由于家庭内依赖而导致的过度分散。
A cohort of offspring of mothers with breast or ovarian cancer diagnosed in 1958-1993 was established using Swedish population-based registers. The children (n = 158,041) were born between 1941 and 1993, and their cancer incidence was followed between 1961 and 1993. A total of 3,257 tumors in 3,102 children were found. Observed numbers of cases were compared with expected numbers based on national calendar year-, age-, and sex-specific incidences. For daughters of women with breast cancer, the standardized morbidity ratios for being diagnosed with breast cancer and ovarian cancer before age 50 years were 1.99 (95% confidence interval (CI): 1.86, 2.14) and 1.28 (95% CI: 1.05, 1.54), respectively. The corresponding figures for daughters of women with ovarian cancer were 1.79 (95% CI: 1.55, 2.07) and 2.38 (95% CI: 1.77, 3.12). The risks were raised if the mother's cancer was diagnosed at a young age, the mother had multiple breast/ovarian diagnoses, or there was a sister with breast/ovarian cancer. Among all offspring, increased risks were found for thyroid cancer, testicular cancer, and malignant melanoma, while lung cancer risk was decreased if the mother had had breast cancer. The authors developed a variance estimator for the standardized morbidity ratio to cope with overdispersion due to dependency within families.