Quantitative 3D ultrashort time-to-echo (UTE) MRI and micro-CT (μCT) evaluation of the temporomandibular joint (TMJ) condylar morphology
Quantitative 3D ultrashort time-to-echo (UTE) MRI and micro-CT (μCT) evaluation of the temporomandibular joint (TMJ) condylar morphology
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DOI：
10.1007/s00256-013-1738-9
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发表时间：
2014-01-01
影响因子：
2.1
通讯作者：
Chung, Christine B.
中科院分区：
文献类型：
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作者：
Geiger, Daniel;Bae, Won C.;Chung, Christine B.
颞下颌关节功能障碍包括颞下颌关节骨关节炎，包括下颌髁的退变和形态改变。本研究的目的是确定新型3D-UTE MRI与micro-CT （mu CT）定量评估下颌髁突形态的准确性。从尸体上采集9个TMJ髁标本（2 M, 3 F；年龄85 +/- 10岁，平均+/- SD）。使用3-T MR扫描仪进行3D-UTE MRI （TR = 50 ms, TE = 0.05 ms， 104 μ m各向同性体素）和mu CT （18 μ m各向同性体素）。MR数据集与mu CT数据集进行空间配准。两名观察员对髁状突的骨轮廓进行了分割。在MR数据集上对纤维软骨进行分割。使用自定义程序，确定骨和纤维软骨表面坐标，高斯曲率，分割区域的体积和纤维软骨厚度，以定量评估关节形态。使用类内相关系数（ICC）分析确定技术（MRI vs mu CT）和观察者（MRI vs MRI）对骨的高斯曲率、平均曲率和分割体积的一致性。MRI与mu CT的表面坐标平均偏差为0.19±0.15 mm，略高于MRI的空间分辨率。分割区域的高斯曲率和体积从MRI到mu CT的平均偏差分别为5.7 +/- 6.5%和6.6 +/- 6.2%。高斯曲率、平均曲率和分割体的ICC系数（MRI vs mu CT）分别为0.892、0.893和0.972。在观察者（MRI与MRI）之间，ICC系数分别为0.998、0.999和0.997。纤维软骨厚度为0.55 +/- 0.11 mm，与先前文献中描述的大体正常TMJ样本相同。3D-UTE MR对TMJ髁突离体形态的定量评价，包括表面、曲率和分割体积，与mu CT和观察者之间具有高度相关性。此外，UTE MRI允许对纤维软骨髁成分进行定量评估。
Temporomandibular dysfunction involves osteoarthritis of the TMJ, including degeneration and morphologic changes of the mandibular condyle. The purpose of this study was to determine the accuracy of novel 3D-UTE MRI versus micro-CT (mu CT) for quantitative evaluation of mandibular condyle morphology.Nine TMJ condyle specimens were harvested from cadavers (2 M, 3 F; age 85 +/- 10 years, mean +/- SD). 3D-UTE MRI (TR = 50 ms, TE = 0.05 ms, 104-mu m isotropic-voxel) was performed using a 3-T MR scanner and mu CT (18-mu m isotropic-voxel) was also performed. MR datasets were spatially registered with a mu CT dataset. Two observers segmented bony contours of the condyles. Fibrocartilage was segmented on the MR dataset. Using a custom program, bone and fibrocartilage surface coordinates, Gaussian curvature, volume of segmented regions, and fibrocartilage thickness were determined for quantitative evaluation of joint morphology. Agreement between techniques (MRI vs. mu CT) and observers (MRI vs. MRI) for Gaussian curvature, mean curvature, and segmented volume of the bone were determined using intraclass correlation coefficient (ICC) analysis.Between MRI and mu CT, the average deviation of surface coordinates was 0.19 +/- 0.15 mm, slightly higher than the spatial resolution of MRI. Average deviation of the Gaussian curvature and volume of segmented regions, from MRI to mu CT, was 5.7 +/- 6.5 % and 6.6 +/- 6.2 %, respectively. ICC coefficients (MRI vs. mu CT) for Gaussian curvature, mean curvature, and segmented volumes were 0.892, 0.893, and 0.972, respectively. Between observers (MRI vs. MRI), the ICC coefficients were 0.998, 0.999, and 0.997, respectively. Fibrocartilage thickness was 0.55 +/- 0.11 mm, as previously described in the literature for grossly normal TMJ samples.3D-UTE MR quantitative evaluation of TMJ condyle morphology ex-vivo, including surface, curvature, and segmented volume, shows high correlation against mu CT and between observers. In addition, UTE MRI allows quantitative evaluation of the fibrocartilaginous condylar component.