AXOTOMY OF THE RAT FACIAL-NERVE LEADS TO INCREASED CR3 COMPLEMENT RECEPTOR EXPRESSION BY ACTIVATED MICROGLIAL CELLS
AXOTOMY OF THE RAT FACIAL-NERVE LEADS TO INCREASED CR3 COMPLEMENT RECEPTOR EXPRESSION BY ACTIVATED MICROGLIAL CELLS
复制标题
DOI：
10.1002/jnr.490210104
复制
发表时间：
1988-09-01
影响因子：
4.2
通讯作者：
KREUTZBERG, GW
中科院分区：
文献类型：
--
作者：
GRAEBER, MB;STREIT, WJ;KREUTZBERG, GW
大鼠面神经切断可导致小胶质细胞有丝分裂，但不发育为吞噬细胞。为了研究那些被激活的小胶质细胞的功能特征，即增殖但不吞噬的小胶质细胞，我们研究了这些细胞的单核/巨噬细胞抗原的表达。我们的结果表明，激活的小胶质细胞缺乏被Ox-41、ED1、ED2和Ki-M2R单抗识别的单核/巨噬细胞抗原，但在原位表达高水平的CR3补体受体。
Axotomy of the rat facial nerve leads to mitotic divisions of microglial cells without developing into phagocytes. In order to study the functional characteristics of those activated, i.e., proliferating but nonphagocytic, microglia we investigated the expression of monocyte/macrophage antigens by these cells. Our results show that activated microglia lack monocyte/macrophage antigens recognized by the monoclonal antibodies Ox-41, ED1, ED2, and Ki-M2R but express high levels of CR3 complement receptors in situ.