Rac1 and PAK1 are upstream of IKK-ε and TBK-1 in the viral activation of interferon regulatory factor-3
Rac1 and PAK1 are upstream of IKK-ε and TBK-1 in the viral activation of interferon regulatory factor-3
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DOI：
10.1016/j.febslet.2004.04.069
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发表时间：
2004-06-04
期刊：
影响因子：
3.5
通讯作者：
Ludwig, S
中科院分区：
文献类型：
--
作者：
Ehrhardt, C;Kardinal, C;Ludwig, S
The anti-viral type I interferon (IFN) response is initiated by the immediate induction of IFNbeta, which is mainly controlled by the IFN-regulatory factor-3 (IRF-3). The signaling pathways mediating viral IRF-3 activation are only poorly defined. We show that the Rho GTPase Rac1 is activated upon virus infection and controls IRF-3 phosphorylation and activity. Inhibition of Rac1 leads to reduced IFNbeta promoter activity and to enhanced virus production. As a downstream mediator of Rac signaling towards IRF-3, we have identified the kinase p21-activated kinase (PAK1). Furthermore, both Rac1 and PAK1 regulate the recently described IRF-3 activators, IkappaB kinase-V and TANK-binding kinase-1, establishing a first canonical virus-induced IRF-3 activating pathway. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
