An excitement subscale of the Positive and Negative Syndrome Scale
An excitement subscale of the Positive and Negative Syndrome Scale
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DOI：
10.1016/s0920-9964(03)00087-2
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发表时间：
2004-06-01
影响因子：
4.5
通讯作者：
Stauffer, VL
中科院分区：
文献类型：
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作者：
Lindenmayer, JP;Browne, E;Stauffer, VL
背景：我们试图开发和验证阳性和阴性综合征量表（PANSS）中的兴奋亚量表，以便在使用PANSS的精神分裂症患者的临床试验中调查躁狂样兴奋症状，并为临床医生提供这些状态的简短评估工具。方法：采用六项奥氮平双盲随机注册试验的基线PANSS数据进行事后分析，其中三项针对精神分裂症（或分裂情性障碍），三项针对急性双相躁狂。精神分裂症的研究数据被汇总并随机分成两半。对半数数据进行探索性主成分因子分析。基于最小特征值准则（特征值大于等于1）提取因子；采用等轴旋转确定载荷。对另一半数据进行验证性主成分因子分析，保留原有因子数。主成分因子分析也用于双相障碍合并研究。在每个双相研究中，新的躁狂样因子得分的变化与青年躁狂评定量表（Y-MRS）得分相关。结果：对合并的精神分裂症数据进行探索性主成分分析，提取出5个因素：消极、积极、兴奋、认知和抑郁因素。躁狂样兴奋因子由四个项目（不合作、冲动控制能力差、兴奋和敌意）表示，只有中等负荷的紧张和怀疑/迫害。验证性分析和合并双相研究的结果相似。躁狂症样因子从基线到终点的变化与双相研究中Y-MRS评分的变化具有相当好的相关性（0.64-0.78）。在基线时，双相情感障碍患者在PANSS躁狂样因素项目中的三项得分高于精神分裂症患者：冲动控制能力差、兴奋和敌意；大多数其他PANSS项目的情况正好相反。结论：PANSS的因素分析一致揭示了兴奋因素包括不合作、冲动控制不良、兴奋和敌意项目。这一因素在检查躁狂症状的研究中可能是有用的，在这些研究中，添加躁狂特有的量表是繁重的，并且兴奋症状是临床表现的一部分。(C) 2003 Elsevier B.V.版权所有
Background: We sought to develop and validate an excitement subscale from the Positive and Negative Syndrome Scale (PANSS) to allow the investigation of mania-like excitement symptoms in clinical trials of patients with schizophrenia using the PANSS and to provide clinicians with a short assessment tool for these states.Methods: Baseline PANSS data from six double-blind, randomized registration trials of olanzapine, three in schizophrenia (or schizoaffective disorder) and three in acute bipolar mania, were used in these post-hoc analyses. Schizophrenia study data were pooled and randomly split in half. Exploratory principal component factor analysis was performed on half of the data. Factors were extracted based on minimum eigenvalue criteria (eigenvalue greater than or equal to 1); loadings were determined using an equamax rotation. Confirmatory principal component factor analysis was performed on the other half of the data, retaining the original number of factors. Principal component factor analysis was also done for the pooled bipolar studies. Change in the new mania-like factor scores was then correlated with Young Mania Rating Scale (Y-MRS) scores in each bipolar study.Results: Exploratory principal components analysis on the pooled schizophrenia data extracted five factors: negative, positive, excitement, cognitive, and depressive factors. The mania-like excitement factor was represented by four items (uncooperativeness, poor impulse control, excitement, and hostility), with only moderate loadings by tension and suspiciousness/persecution. Results were similar in the confirmatory analysis and the pooled bipolar studies. Change from baseline to endpoint for the mania-like factor correlated reasonably well (0.64-0.78) with change in Y-MRS scores in the bipolar studies. At baseline, bipolar patients scored higher than patients with schizophrenia on three of four PANSS mania-like factor items: poor impulse control, excitement, and hostility; the converse was true for most other PANSS items.Conclusion: Factor analyses of the PANSS consistently uncovered an excitement factor including uncooperativeness, poor impulse control, excitement, and hostility items. This factor may be useful in examining manic symptoms in studies where the addition of a scale specific to mania would be burdensome and where symptoms of excitement are part of the clinical presentation. (C) 2003 Elsevier B.V. All rights reserved.