Xyloglucan-based hydrogel films for wound dressing: Structure-property relationships
Xyloglucan-based hydrogel films for wound dressing: Structure-property relationships
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DOI：
10.1016/j.carbpol.2017.09.092
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发表时间：
2018-01-01
影响因子：
11.2
通讯作者：
Dispenza, Clelia
中科院分区：
文献类型：
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作者：
Ajovalasit, Alessia;Sabatino, Maria Antonietta;Dispenza, Clelia
木葡聚糖基水凝胶薄膜的合成和表征具有制备伤口敷料的前景。添加聚乙烯醇（PVA）和甘油（Gro）以具有柔软性、适形性和回弹性的最佳组合。通过与戊二醛（GA）反应，物理水凝胶已转化为永久性共价水凝胶。网络结构-工艺-性能的关系进行了讨论的几个互补的表征：FTIR，流变学，热分析，形态分析，保湿和溶胀测量的结果。还对选定的制剂进行了初步体外细胞毒性试验。所产生的一些基于木葡聚糖的水凝胶膜的物理和机械性质，加上没有细胞毒性，使它们成为与传感器集成的合适候选物，以监测伤口愈合过程和动物模型中的进一步生物学研究。
Thin xyloglucan-based hydrogel films have been synthetized and characterized in the prospect of producing wound dressings. Polyvinyl alcohol (PVA) and glycerol (Gro) were added to have an optimal combination of softness, conformability and resilience. Physical hydrogels have been transformed into permanent covalent hydrogels by reaction with glutaraldehyde (GA). Network structure-process-property relationships are discussed on the account of the results of several complementary characterizations: FTIR, rheology, thermal analysis, morphological analysis, moisture retention and swelling measurements. Selected formulations were also subjected to preliminary in vitro cytotoxicity tests. The physical and mechanical properties of some of the xyloglucan-based hydrogel films produced, combined with absence of cytotoxicity, make them suitable candidates for integration with sensors to monitor the wound healing process and further biological investigations in animal models.