Prenatal exposure to low-level polychlorinated biphenyls in relation to mental and motor development at 8 months
Prenatal exposure to low-level polychlorinated biphenyls in relation to mental and motor development at 8 months
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DOI：
10.1093/aje/kwg010
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发表时间：
2003-03-15
影响因子：
5
通讯作者：
Needham, LL
中科院分区：
文献类型：
--
作者：
Daniels, JL;Longnecker, MP;Needham, LL
在几项研究中，人们研究了幼儿接触低水平的多氯联苯(PCBS)与认知和运动发育之间的关系，结果各不相同。作者使用来自合作围产期项目的数据评估了产前暴露于多氯联苯和儿童神经发育之间的联系。孕妇从1959年到1965年从12个地点登记。在美国各地。在怀孕期间采集的母体血清中检测多氯联苯。为了测量8个月大时儿童的智力和精神运动发育，作者使用了贝利婴儿发育量表(平均值分别为87(标准差，15)和88(标准差，18))。总体而言，他们没有观察到产前接触多氯联苯与儿童的精神或精神运动得分之间的关系(n=1,207；多变量调整后的β=每杯/升多氯联苯增加01分，p=0.71，和b=0.5，p=0.14)。不同研究中心之间的心理运动得分关系不同(p<；0.05)：这种联系在一些中心是正的，在另一些中心是相反的。这不能归因于儿童神经发育或多氯联苯分析的时间或测量的差异，因为这些都是跨中心标准化的。这项研究和其他研究结果不同的原因尚不清楚。
The relation between exposure to low levels of polychlorinated biphenyls (PCBs), a class of persistent organic pollutants, and.cognitive and motor development in young children has been examined in several studies, and results have varied. The authors evaluated the association between prenatal exposure to PCBs and children's neurodevelopment using data from the Collaborative Perinatal Project. Pregnant women were enrolled from 1959 to 1965 from 12 sites. across the United States. PCBs were measured in maternal serum taken during pregnancy. To measure children's mental and psychomotor development at 8 months of age, the authors administered the Bayley Scales of Infant Development (means, 87 (standard deviation, 15) and 88 (standard deviation, 18), respectively). Overall, they did not observe a relation between prenatal PCB exposure and children's mental or psychomotor scores (n = 1,207; multivariate adjusted beta = 01 point per mug/liter increase of PCB, p = 0.71, and beta = 0.5, p = 0.14, respectively). The PCB-psychomotor score relation varied by study center (p < 0.05): The association was direct in some centers, inverse in others. This could not be attributed to variation in the timing or measurement of the child's neurodevelopment or analysis of PCBs because these were standardized across centers. The reasons for variation in results within this study and across other studies remain unclear.