Mechanisms and Functions of Pexophagy in Mammalian Cells.
Mechanisms and Functions of Pexophagy in Mammalian Cells.
复制标题
哺乳动物细胞自噬的机制和功能
作者：
Li J;Wang W
过氧酶体在多种细胞代谢功能中起着至关重要的作用，其动态平衡是通过过氧酶体的生物发生和周转的协调来维持的。吞噬作用是过氧化物体选择性自噬降解的一种，是清除受损和/或多余的过氧化物体的主要机制。吞噬功能的失调损害了过氧化体的生理功能，并导致了许多人类疾病的进展。然而，与酵母细胞相比，哺乳动物细胞中的吞噬作用的机制和功能仍然很大程度上是未知的。本文就哺乳动物食欲的研究进展作一综述，旨在加深对食欲在人类健康和疾病中作用的认识。越来越多的证据表明，泛素化可以作为食欲的信号，泛素结合受体、底物和参与食欲的E3连接酶/脱泛素酶已被描述。此外，还可以通过不依赖泛素的方式来实现食欲。我们讨论了这些泛素依赖和泛素非依赖的吞食途径的机制，并总结了目前用于研究吞噬的几个诱导条件。我们强调了食欲癖在人类健康中的几个角色，以及它的失调如何可能导致疾病。
Peroxisomes play essential roles in diverse cellular metabolism functions, and their dynamic homeostasis is maintained through the coordination of peroxisome biogenesis and turnover. Pexophagy, selective autophagic degradation of peroxisomes, is a major mechanism for removing damaged and/or superfluous peroxisomes. Dysregulation of pexophagy impairs the physiological functions of peroxisomes and contributes to the progression of many human diseases. However, the mechanisms and functions of pexophagy in mammalian cells remain largely unknown compared to those in yeast. This review focuses on mammalian pexophagy and aims to advance the understanding of the roles of pexophagy in human health and diseases. Increasing evidence shows that ubiquitination can serve as a signal for pexophagy, and ubiquitin-binding receptors, substrates, and E3 ligases/deubiquitinases involved in pexophagy have been described. Alternatively, pexophagy can be achieved in a ubiquitin-independent manner. We discuss the mechanisms of these ubiquitin-dependent and ubiquitin-independent pexophagy pathways and summarize several inducible conditions currently used to study pexophagy. We highlight several roles of pexophagy in human health and how its dysregulation may contribute to diseases.
登录
查看更多内容
影响因子：
4.8
作者：
Guo, Dongsheng;Sarkar, Joy;Reddy, Janardan K.
通讯作者：
Reddy, Janardan K.
影响因子：
21.3
作者：
通讯作者：
--
影响因子：
3.8
作者：
Hiebler S;Masuda T;Hacia JG;Moser AB;Faust PL;Liu A;Chowdhury N;Huang N;Lauer A;Bennett J;Watkins PA;Zack DJ;Braverman NE;Raymond GV;Steinberg SJ
通讯作者：
Steinberg SJ
影响因子：
6
作者：
Dutta, Raghbendra Kumar;Maharjan, Yunash;Park, Raekil
通讯作者：
Park, Raekil
DOI：
10.1073/pnas.95.15.8630
发表时间：
1998-07-21
影响因子：
11.1
作者：
Geisbrecht, BV;Collins, CS;Gould, SJ
通讯作者：
Gould, SJ