Clinical value of FDG-PET for preoperative evaluation of endometrial cancer
Clinical value of FDG-PET for preoperative evaluation of endometrial cancer
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DOI：
10.1007/s12149-011-0474-2
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发表时间：
2011-05-01
影响因子：
2.6
通讯作者：
Togashi, Kaori
中科院分区：
文献类型：
--
作者：
Suga, Tsuyoshi;Nakamoto, Yuji;Togashi, Kaori
18氟脱氧葡萄糖（FDG）全身正电子发射断层扫描（PET）已广泛应用于各种恶性肿瘤，但FDG-PET对子宫内膜癌的临床价值尚未得到充分研究。本研究的目的是评估FDG-PET在子宫内膜癌术前评估中的作用。所有患者均接受FDG-PET或PET/CT扫描，并对图像进行目视判读。在检测原发肿瘤，区域淋巴结状态和远处转移的诊断性能进行了测定。此外，PET的有用性进行了评估，在额外的信息和治疗管理的临床影响。40例患者中，30例经组织学证实患有子宫内膜癌。FDG-PET对原发性肿瘤的敏感性和特异性分别为83%和100%，对淋巴结转移的敏感性和特异性分别为100%和100%。有12例远处转移癌6例，2例第二原发癌，这都是准确诊断的PET患者的基础上。PET在10例患者中获得了12个额外的发现，并对4例患者的治疗管理产生了影响，其中包括1例复发性乳腺癌患者。FDG-PET在子宫内膜癌中具有相当高的诊断准确性。尽管具有临床影响的病例数量有限，但在三分之一的病例中获得了PET的额外信息。
Whole body positron emission tomography (PET) with F-18 fluorodeoxyglucose (FDG) has been widely used in various malignancies, but the clinical value of FDG-PET for endometrial cancer has not been fully investigated. The purpose of this study was to evaluate the usefulness of FDG-PET for preoperative evaluation of endometrial cancer.Forty female patients suspected of having endometrial cancer were included in this study. All patients underwent an FDG-PET or PET/CT scan, and images were interpreted visually. The diagnostic performance in detecting the primary tumor, regional nodal status, and distant metastasis was determined. In addition, the usefulness of PET was assessed in terms of additional information and clinical impact for therapeutic management.Of 40 patients, 30 were histologically confirmed to have endometrial cancer. The patient-based sensitivity and specificity of FDG-PET for primary tumors were 83 and 100%, respectively, and 100 and 100%, respectively, for nodal metastases. There were 12 distant metastases in 6 patients and two second primary cancers in two patients, which were all accurately diagnosed by PET on a patient-basis. PET yielded 12 additional findings in 10 patients, and had a bearing on the therapeutic management of four patients, including one patient with recurrent breast cancer.FDG-PET had a reasonably high diagnostic accuracy in endometrial cancer. Although the number of cases with clinical impact was limited, additional information by PET was obtained in one-third of the cases.