Is protein folding hierarchic? I. Local structure and peptide folding
Is protein folding hierarchic? I. Local structure and peptide folding
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DOI：
10.1016/s0968-0004(98)01346-2
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发表时间：
1999-01-01
影响因子：
13.8
通讯作者：
Rose, GD
中科院分区：
文献类型：
--
作者：
Baldwin, RL;Rose, GD
一些小蛋白质的折叠反应显示出明显的分层过程的证据，而其他的，缺乏可检测的中间体，没有。然而，我们认为，这两个类折叠层次和折叠开始本地。如果是这样的话，那么蛋白质的二级结构在很大程度上是由局部序列信息决定的。实验数据和理论考虑支持这一论点。本文的第一部分综述了蛋白质二级结构与多肽二级结构之间的关系。
The folding reactions of some small proteins show clear evidence of a hierarchic process, whereas others, lacking detectable intermediates, do not. Nevertheless, we argue that both classes fold hierarchically and that folding begins locally. If this is the case, then the secondary structure of a protein is determined largely by local sequence information. Experimental data and theoretical considerations support this argument. Part I of this article reviews the relationship between secondary structures in proteins and their counterparts in peptides.