The possible significance of hexosephosphoric esters in ossification.
The possible significance of hexosephosphoric esters in ossification.
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DOI：
10.1042/bj0170286
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发表时间：
1923-01-01
影响因子：
4.1
通讯作者：
Robison, R
中科院分区：
文献类型：
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作者：
Robison, R
己二磷酸是由哈登和杨[1905]以及伊万诺夫[1905]在酵母汁发酵葡萄糖、果糖或甘露糖的产物中发现的，并由杨[1909年，1911年]证明具有C6H1004 (PO4H2) 2的结构，并在水解时产生果糖。两个磷酸分子中的一个很容易通过用弱酸煮沸酯来去除，Neuberg[1918]用这种方法得到了一种六糖膦酸C6H1105 (PO4H2)，与二磷酸酯一样，它具有非常轻微的右旋性，进一步水解会产生左旋糖。哈登和罗宾逊[1914]在酵母汁发酵糖的产物中发现了一种六糖二磷酸酯，罗宾逊[1922]在本刊最近一期的文章中描述了这种酯的分离和研究。它与Neuberg制备的化合物完全不同，它具有很强的右旋性，在水解时产生右旋糖。此外，这种酯中的磷酸基团比己二磷酸中的任何一个基团用酸煮沸去除的速度都要慢得多。二磷酸酯的钡盐和钙盐在冷水中难溶，在热水中更难溶。相反，单磷酸酯则很容易溶于水。在动物生理学方面，Embden及其同事提出了令人信服的证据[Embden and Lacquer， 1921]，表明这种或某些密切相关的磷酸酯存在于条纹肌中，与“致乳剂”相同，从而引起了人们的极大兴趣和意义。
Hexosediphosphoric acid was discovered by Harden and Young [1905] and by Ivanov [1905] among the products of the fermentation of glucose, fructose or mannose by yeast juice in presence of phosphates, and was shown by Young [1909, 1911] to possess the constitution C6H1004 (PO4H2) 2 andto yield fructose on hydrolysis. One of the two phosphoric acid molecules is very easily removed by boiling the ester with weak acids and in this way Neuberg [1918] obtained a hexosemonophosphoric acid C6H1105 (PO4H2) which like the diphosphoric ester is very slightly dextrorotatory and yields a laevorotatory sugar on further hydrolysis.The presence of a hexosemonophosphoric ester was observed by Harden and Robison [1914] among the products of fermentation of sugar by yeast juice, and the isolation and investigation of this ester has been described by Robison [1922] in a recent number of this Journal. It is entirely different from the compound prepared by Neuberg, being strongly dextrorotatory and yielding a dextrorotatory sugar on hydrolysis. The phosphoric acid group in this ester is moreover much more slowly removed by boiling with acids than either of the groups in hexosediphosphoric acid. The barium and calcium salts of the diphosphoric ester are sparingly soluble in cold and still less soluble in hot water. Those of the monophosphoric esters are on the contrary very easily soluble in water. In animal physiology hexosediphosphoric acid has acquired great interest and significance through the researches of Embden and his co-workers who have brought forward convincing evidence [Embden and Lacquer, 1921] that this or some closely related phosphoric ester is present in striped muscle and is identical with the" lactacidogen."