Organocatalytic formal [2+2] cycloaddition initiated by vinylogous Friedel-Crafts alkylation: enantioselective synthesis of substituted cyclobutane derivatives
Organocatalytic formal [2+2] cycloaddition initiated by vinylogous Friedel-Crafts alkylation: enantioselective synthesis of substituted cyclobutane derivatives
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由插烯Friedel-Crafts烷基化引发的有机催化形式[2 2]环加成：取代环丁烷衍生物的对映选择性合成
DOI：
10.1039/c3cc41785a
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
Xu, Peng-Fei
中科院分区：
文献类型：
--
作者：
Duan, Guo-Jian;Ling, Jun-Bing;Xu, Peng-Fei
成功地开发了一种基于串联最小烯胺活化的有机催化乙烯基Friedel-Crafts烷基化引发的[2+2]环加成反应。具有三个连续立体中心的可转化吡咯功能化环丁烷具有优异的区域、非立体和对映控制水平。
An organocatalytic vinylogous Friedel-Crafts alkylation-initiated formal [2+2] cycloaddition was successfully developed based on tandem iminium-enamine activation of enals. Transformable pyrrole-functionalized cyclobutanes with three contiguous stereo-centers were readily obtained with excellent levels of regio-, diastereo- and enantiocontrol.