Effect of cyto/chemokine degradation in effective intercellular communication distances.
Effect of cyto/chemokine degradation in effective intercellular communication distances.
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DOI：
10.1016/j.physa.2016.10.098
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发表时间：
2017-02-15
期刊：
影响因子：
3.3
通讯作者：
Gupta VK
中科院分区：
文献类型：
--
作者：
Gupta VK
许多复杂的生物学过程，如细胞分化、细胞增殖和细胞运动，都是由细胞信号传导控制的。这种细胞间通讯的模式对组织功能以及最终对整个生物体至关重要。在细胞间通讯中，细胞分泌信号分子如细胞因子/趋化因子，其通过周围介质扩散并最终结合到其他细胞上的受体，从而完成信号转导。有效的通信距离和信号发生的时间尺度的准确估计对于解释细胞和器官生理学以及最终在有效和高效的趋化性驱动的组织工程中是重要的。本研究使用一个单独的细胞模型，结合分泌分子的降解，以估计有效的通信距离和信号发生的时间尺度。我们通过我们的模型证明，在存在退化的有效通信距离显着减少。
Many complex biological processes such as cell differentiation, cell proliferation, and cell motility are governed by cell signaling. This mode of intercellular communication is of paramount importance for tissue function and ultimately for entire organism. In intercellular communication cells secrete signaling molecules such as cyto/chemokines which diffuse through the surrounding medium and eventually bind to receptors on other cells whereby the signal transduction is completed. An accurate estimation of the effective communication distances and the time scale on which signaling takes place are important for the interpretation of cell and organ physiology and ultimately in the effective and efficient chemotactically driven tissue engineering. The present study uses a solitary cell model incorporating degradation of secreted molecules to estimate the effective communication distances and the time scale on which signaling takes place. We demonstrate through our model that in presence of degradation the effective communication distances are significantly reduced.