Association between CHRNA3 rs1051730 Genotype and Lung Cancer Risk in Chinese Han Population: A Case-Control Study
Association between CHRNA3 rs1051730 Genotype and Lung Cancer Risk in Chinese Han Population: A Case-Control Study
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CHRNA3 rs1051730 基因型与中国汉族人群肺癌风险的关联：病例对照研究
DOI：
10.1007/s11596-013-1218-4
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发表时间：
2013-12-01
影响因子：
--
通讯作者：
Zhang, Tao
中科院分区：
文献类型：
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作者：
Ren, Jing-hua;Jin, Min;Zhang, Tao
近年来，基于人群的全基因组关联研究发现，在染色体15q25.1区域含有烟碱型乙酰胆碱受体基因，是肺癌的潜在易感位点。增加肺癌风险的基因座在高加索人中已被广泛确定，但这种关联是否也存在于亚洲人中，以及这种关联是直接作用还是通过吸烟间接介导的尚未完全确定。我们进行了一项病例对照研究，包括210例组织学确诊的肺癌病例和200名健康对照，以检查rs 1051730基因型，一个单核苷酸多态性最近受到关注，及其对肺癌的风险和尼古丁依赖的影响，在中国汉族人群。结果表明，C/T杂合子基因型和T等位基因与CC纯合子和C等位基因相比，其患肺癌的危险性显著增高（校正OR=2.25，95%CI =1.04-4.89，P=0.040和OR=2.18，95%CI =1.02-4.67，P=0.045）。然而，在这项研究中没有观察到吸烟习惯和CHRNA 3 rs 1051730多态性之间的关联。研究结果提示rs 1051730基因多态性可能通过非吸烟方式影响中国汉族人群肺癌的易感性。进一步的体外和体内研究是必要的，以进一步阐明rs 1051730对肺癌易感性的影响。
Recent population-based genome wide association studies have revealed potential susceptibility loci of lung cancer at the region of chromosome 15q25.1 containing nicotinic acetylcholine receptor genes. The loci increasing lung cancer risk has been widely identified in Caucasians, but whether this association also exists in Asians and whether this association is a direct role or mediated via tobacco smoking indirectly has not been fully established. We conducted a case-control study comprising of 210 histologically confirmed lung cancer cases and 200 healthy controls to examine rs1051730 genotyping, a single nucleotide polymorphism receiving much attention recently, and its influence on lung cancer risk as well as nicotine dependence in a Chinese Han population. Our results showed that the heterozygous C/T genotype and minor allele T conferred a significant higher risk of lung cancer than the CC homozygotes and allele C (adjusted OR=2.25, 95% CI=1.04-4.89, P=0.040 and OR=2.18, 95% CI=1.02-4.67, P=0.045 respectively). However, no association between the smoking habit and the CHRNA3 rs1051730 polymorphism was observed in this study. The results suggested that the rs1051730 polymorphism may modify susceptibility to lung cancer via a smoking-independent manner among Chinese Han population. Additional studies in vitro and in vivo are warranted to further elucidate the impact of rs1051730 on lung cancer susceptibility.