Congenital malformations detected in 731 autopsies of children aged 0 to 14 years.
Congenital malformations detected in 731 autopsies of children aged 0 to 14 years.
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731 例 0 至 14 岁儿童尸检中发现先天畸形。
DOI：
10.1002/tera.1420350303
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
H. Haase
中科院分区：
文献类型：
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作者：
T. C. Mattos;R. Giugliani;H. Haase
对 1977 年至 1982 年阿雷格里港大学医院病理解剖服务中心进行的 731 例 0 至 14 岁儿童尸检进行回顾性研究，以确定先天畸形的频率、类型和严重性。受试者被分为五个年龄范围：死产（6）、0至24小时（42）、1至30天（50）、1至12个月（24）和1至14岁（9）。畸形被分类为单一或多重（存在两个或多个独立缺陷），并评估它们对死亡的影响。 131 例尸检中发现先天性畸形（18%）。在大多数情况下，缺陷是单一的（91），最常见的缺陷涉及心血管系统（37）和泌尿生殖系统（21）。在患有多种畸形的患者（40 例）中，心血管系统（24 例）和泌尿生殖系统（19 例）也最常受累。骨关节系统的缺陷也经常出现在具有多种缺陷的患者中（25），尽管其中大多数是由机械因素引起的变形。按比例来说，先天畸形在 0 至 24 小时范围内最常见，其中多个缺陷与单个缺陷的比例最高 (1:1)。在 131 例病例中，76% 的死亡被认为是先天性畸形造成的（87% 为多缺陷患者，60% 为单一缺陷患者）。我们相信，本研究中收集的数据可能有助于更好地了解先天性畸形在儿童死亡率中所起的作用。
A retrospective study of 731 autopsies of children aged 0 to 14 years, performed in the Pathological Anatomy Service of the University Hospital of Porto Alegre from 1977 to 1982, was carried out to determine the frequency, type, and seriousness of congenital malformations. The subjects were divided into five age ranges: stillborn (6), 0 to 24 hours (42), 1 to 30 days (50), 1 to 12 months (24), and 1 to 14 years (9). The malformations were classified as single or multiple (presence of two or more independent defects), and their contribution to death was evaluated. Congenital malformations were detected in 131 autopsies (18%). In most cases the defects were single (91), and the most common ones involved the cardiovascular system (37) and the genitourinary system (21). In the patients with multiple malformations (40), the cardiovascular system (24) and the genitourinary system (19) were also most frequently involved. Defects of the osteoarticular system were also frequently encountered in patients with multiple defects (25), although most of them were deformations caused by mechanical factors. Proportionally, congenital malformations were most frequently detected in the 0 to 24 hours range, which also included the highest proportion of multiple defects in relation to single ones (1:1). Congenital malformations were considered responsible for death in 76% of the 131 cases (87% of the multiple defects patients and 60% of the single defect patients). We believe that the data collected in the present study may contribute to a better understanding of the role played by congenital malformations in child mortality.