Impact of menthol inhalation on nasal mucosal temperature and nasal patency
Impact of menthol inhalation on nasal mucosal temperature and nasal patency
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DOI：
10.2500/ajr.2008.22.3194
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发表时间：
2008-07-01
期刊：
影响因子：
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通讯作者：
Wiesmiller, Kerstin M.
中科院分区：
文献类型：
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作者：
Lindemann, Joerg;Tsakiropoulou, Evangelia;Wiesmiller, Kerstin M.
背景：薄荷脑是一种天然草药化合物。其同分异构体L-薄荷醇具有薄荷的特有气味，也是由于刺激三叉神经冷感受器而应用于鼻粘膜表面时产生凉感的原因。本研究的目的是评价吸入薄荷醇对吸气末鼻黏膜温度和鼻腔通畅度的影响。方法：18名健康志愿者，平均年龄30岁。目的用微型热电偶测量吸入L薄荷脑蒸气前后鼻瓣区的鼻中隔粘膜温度，并进行主动前鼻压测量。所有受试者在吸入薄荷醇前后完成视觉模拟评分(VAS；范围1-10)以评估鼻腔通畅性。结果：平均吸气末粘膜温度从吸入薄荷醇前的27.7℃(+/-4.0)到吸入薄荷醇后的28.5℃(+/-3.5)。吸入薄荷醇前后体温值差异无统计学意义(p>；0.05)。此外，在薄荷脑吸入前后的鼻压值之间没有统计学上的显著差异。18例受试者中有16例报告通过VAS吸入薄荷脑后鼻呼吸得到改善。结论：薄荷脑吸入对鼻粘膜温度和鼻气流量没有影响。鼻气流改善的主观印象支持这样一个事实，即薄荷醇会直接刺激调节凉爽感觉的冷感受器，从而产生清晰而宽大的鼻子的主观感觉。
Background: Menthol is a natural herbal compound. Its isomer L-menthol presents the characteristic peppermint scent and is also responsible for the cooling sensation when applied to nasal mucosal surfaces because of stimulation of trigeminal cold receptors. The aim of this study was to assess the effect of menthol inhalation on end-inspiratory nasal mucosa temperature and nasal patency.Methods: Eighteen healthy volunteers with a mean age of 30 years were enrolled in this study. Objective measurements included the septal mucosal temperature within the nasal valve area by using a miniaturized thermocouple as well as active anterior rhinomanometry before and after inhalation of l-menthol vapor. All subjects completed a visual analog scale (VAS; range, 1-10) evaluating nasal patency before and after menthol.Results: The mean end-inspiratory mucosal temperature anged from 27.7 degrees C (+/- 4.0) before menthol inhalation to 28.5 degrees C (+/- 3.5) after menthol inhalation. There were no statistically significant differences between the temperature values before and after menthol inhalation (p > 0.05). In addition, no statistically significant differences between the rhinomanometric values before and after menthol inhalation were observed. Sixteen of the 18 subjects reported an improvement of nasal breathing after menthol inhalation by means of the VAS.Conclusion: Menthol inhalation does not have an effect on nasal mucosal temperature and nasal airflow. The subjective impression of an improved nasal airflow supports the fact that menthol leads to a direct stimulation of cold receptors modulating the cool sensation, entailing the subjective feeling of a clear and wide nose.