Effect of fractionated radiotherapy on salivary gland function
Effect of fractionated radiotherapy on salivary gland function
复制标题
分割放疗对唾液腺功能的影响
作者：
C. Eneroth;C. O. Henrikson;P. Jakobsson
对4例接受4000、6400拉德照射的头颈部恶性肿瘤患者，采用腮腺造影和腮腺唾液流率测量的方法，研究了分次放疗对涎腺功能的影响。在照射开始和结束时及8个月后进行唾液管造影术。在整个治疗期间和8个月后，用唾液测定法测定每次照射(每日剂量200rad)后的唾液分泌率。尽管此时唾液分泌速率明显紊乱，但在照射结束时，腺体的大小没有变化。因此，可以说，受照射的腮腺的大小并不像正常的腺体那样是其功能的标准。不可能确定一个临界剂量水平，从而产生病理性的低唾液分泌物。即使在高剂量分割放射治疗后，腮腺功能也已恢复。对“非肿瘤”侧腮腺进行400-600拉德剂量的照射，这些小剂量没有引起唾液分泌率低于正常变化。
The effect of fractionated radiotherapy on salivary gland function was studied by sialography and sialometry of parotid glands in four patients irradiated with 4000 or 6400 rads for malignant tumors of the head and neck region. Sialography was performed at the beginning and end of the irradiation period and 8 months later. By sialometry, the salivary secretion rate was determined after each irradiation treatment (a daily dose of 200 rads) during the whole treatment period and again 8 months later. The size of the glands was found to be unchanged at the end of the irradiation period despite the pronounced disturbance of the salivary secretion rate at this time. Thus it can be stated that the size of irradiated parotid glands is not a criterion of their function as in the case of normal glands. It was not possible to identify a critical dose level giving a pathologically low salivary secretion. Even after high doses in fractionated radiotherapy, a recovery of the parotid gland function has been found. Parotid glands on the “non‐tumor” side were irradiated with a dose of between 400 and 600 rads, and these small doses did not cause a reduction of salivary secretion rate below normal variation.