Superiority of lipoprotein particle number to detect associations with arterial thickness and stiffness in obese youth with and without prediabetes.
Superiority of lipoprotein particle number to detect associations with arterial thickness and stiffness in obese youth with and without prediabetes.
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DOI：
10.1016/j.jacl.2016.01.007
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发表时间：
2016-05
影响因子：
4.4
通讯作者：
Urbina EM
中科院分区：
文献类型：
--
作者：
Shah AS;Davidson WS;Gao Z;Dolan LM;Kimball TR;Urbina EM
The nuclear magnetic resonance (NMR) lipoprotein profile provides additional cardiovascular risk information beyond traditional lipids in high risk adults. Similar studies have not been conducted in youth. To evaluate the relationship between the NMR profile and pre-clinical vascular measures in youth. We studied 96 obese youth with pre-diabetes (mean age 18.1±3.6 years, 63% female, 78% African-American) and 118 obese normoglycemic controls (mean age 18.0±3.1 year, 75% female, 62% African American) cross-sectionally. Traditional lipids (triglycerides, total, HDL and LDL cholesterol), NMR particle size (particle concentration (P) and size) and vascular thickness (carotid IMT) and stiffness (pulse wave velocity (PWV)) were measured. Independent associations between lipoproteins with carotid IMT and PWV after adjustment for group, age, race, sex, BMI z score, blood pressure, HOMA-IR and A1c were studied. NMR analysis revealed youth with pre-diabetes exhibited a more atherogenic profile with higher levels of small LDL-P and HDL-P and lower levels of intermediate and large HDL-P (p<0.03). In addition, lower intermediate HDL-P was associated with a higher carotid IMT while higher small HDL-P was associated with a higher PWV (p<0.01). Traditional lipids were not significantly different between groups and were not associated with either vascular outcome. NMR lipoprotein subclasses have improved sensitivity compared to traditional lipids to detect lipoprotein abnormalities in normoglycemic and pre-diabetic obese youth and are independently associated with pre-clinical vascular thickness and stiffness. Whether this enhances future cardiovascular risk in youth needs to be determined.
