Electrocardiogram in evaluation of resistance to antihypertensive therapy.
Electrocardiogram in evaluation of resistance to antihypertensive therapy.
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心电图评估抗高血压治疗的抵抗力。
DOI：
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发表时间：
1977
影响因子：
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通讯作者：
R. Gifford
中科院分区：
文献类型：
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作者：
M. Ibrahim;R. Tarazi;H. Dustan;R. Gifford
本文对50例高血压病患者进行了平均9年的随访，观察了血压控制对左室肥厚心电图改变的影响。血压对治疗的反应是通过随意的办公室读数和每周平均每天两次的家庭读数来确定的。心电图的改变，从QRS电压和ST-T段的改变来看，与动脉压控制的程度有关。通常，家庭和办公室动脉血压对降压治疗的反应相似，但当存在差异时，心电图变化与家庭平均血压的相关性最好。最大胸前QRS电压(Sv1+Rv5-6)的降低与家庭收缩压变化的相关性最好(r=.460；P<.001)，但与家庭或办公室的舒张压变化的相关性均未达到统计学意义(P>.10)。目前的数据强调了家庭压力测量在一些高血压患者管理中的重要性，并提供了证据表明，临时的办公室读数有时可能会误判抗高血压治疗的有效性。
The effect of blood pressure control on the evolution of electrocardiographic evidence of left ventricular hypertrophy was investigated 50 patients with hypertension who were followed up for an average period of nine years. Blood pressure response to treatment was determined both from casual office readings and from weekly averages of twice daily home readings. Changes in the ECG, judged from both alteration in QRS voltage and in ST-T segment, were related to the degree of arterial pressure control. Usually, both home and office arterial pressure responded similarly to antihypertensive therapy, but when there was a difference, electrocardiographic changes correlated best with home prssure averages. Reduction in maximum precordial QRS voltage (Sv1+Rv5-6) correlated best with changes in home systolic pressure (r = .460; P less than .001), but correlation with diastolic pressure variation either at home or in the office did not attain statistical significance (P greater than .10). The present data stress the importance of home pressure measurements in the management of some patients with hypertension and provide evidence that casual office readings may sometimes misjudge the effectiveness of antihypertensive therapy.