Food restriction neither improves nor exacerbates reproduction in obese female Zucker rats.
Food restriction neither improves nor exacerbates reproduction in obese female Zucker rats.
复制标题
食物限制既不会改善也不会加剧肥胖雌性 Zucker 大鼠的繁殖。
DOI：
10.1016/s0031-9384(99)00006-2
复制
发表时间：
1999
影响因子：
2.9
通讯作者：
Olster,DH
中科院分区：
文献类型：
--
作者：
Marín-Bivens,CL;Olster,DH
马隆-比文斯角L.和D. H.奥斯特。食物限制既不改善也不加剧肥胖雌性Zucker大鼠的生殖。《物理学》第五卷，第66卷，第5期，第893-897页，1999年。肥胖雌性Zucker大鼠有几种生殖异常，包括青春期延迟，异常发情周期，和卵巢类固醇激素的行为低反应性。为了确定体重过重本身是否会导致这些生殖异常，对肥胖的Zucker雌性大鼠随意喂食或限制食物，以使其体重与瘦大鼠的体重相匹配。限食既不能加速肥胖雌性大鼠的阴道开放，也不能使动情周期正常化。卵巢切除术后，注射苯甲酸雌二醇（EB，15 μg/kg，s.c.）在所有大鼠中诱导极低的性感受性，从未观察到性行为。在用EB加孕酮（P，2 mg/kg，s.c.）处理后，瘦大鼠非常容易接受（脊柱前凸商数，LQ = 94 ± 2%）和接受（PRO = 12.5 ± 2事件/分钟），而自由进食和食物限制的肥胖大鼠仅具有轻微的接受和接受（分别为LQ= 19 ± 9%，PRO = 1.8 ± 0.7事件/分钟; LQ = 31 ± 15%，PRO = 4.7 ± 3事件/分钟）。较高的孕酮剂量（20 mg/kg）在所有EB处理的大鼠中引起强烈的性感受性（LQ = 88-99%）和感知性（PRO = 16.5-20.4事件/分钟）。与自由进食的肥胖大鼠相比，限制食物的肥胖大鼠的肥胖率显著较低（36.5 ± 1.7% vs. 69.4 ± 2.7%），但高于在瘦大鼠中观察到的肥胖率（24.4 ± 1.1%）。这些数据表明，超重本身并不构成肥胖Zucker大鼠生殖异常的基础，但不排除过度肥胖可能导致其不育的可能性。
MARÍN–BIVENS, C. L. AND D. H. OLSTER. Food restriction neither improves nor exacerbates reproduction in obese female Zucker rats. PHYSIOL BEHAV 66(5) 893–897, 1999.—Obese female Zucker rats have several reproductive abnormalities, including delayed puberty, abnormal estrous cyclicity, and behavioral hyporesponsiveness to ovarian steroid hormones. To ascertain whether excessive body weight per se causes these reproductive abnormalities, obese Zucker female rats were fed ad lib or were food restricted to match their body weights to those of lean counterparts. Food restriction neither accelerated vaginal opening nor normalized estrous cyclicity in obese female rats. Following ovariectomy, an injection of estradiol benzoate (EB, 15 μg/kg, s.c.) induced extremely low sexual receptivity in all rats, and proceptive behaviors were never observed. After treatment with EB plus progesterone (P, 2 mg/kg, s.c.), lean rats were very receptive (lordosis quotient, LQ = 94 ± 2%) and proceptive (PRO = 12.5 ± 2 events/min) while both ad lib-fed and food-restricted obese rats were only marginally receptive and proceptive (LQ= 19 ± 9%, PRO = 1.8 ± 0.7 events/min; LQ = 31 ± 15%, PRO = 4.7 ± 3 events/min, respectively). A higher progesterone dose (20 mg/kg) elicited vigorous sexual receptivity (LQ = 88–99%) and proceptivity (PRO = 16.5–20.4 events/min) in all EB-treated rats. Adiposity was significantly lower in food-restricted obese rats as compared to ad lib-fed obese rats (36.5 ± 1.7% vs. 69.4 ± 2.7%), but greater than that observed in lean rats (24.4 ± 1.1%). These data suggest that excessive body weight per se does not underlie reproductive abnormalities in obese Zucker rats, but do not rule out the possibility that excessive adiposity may contribute to their infertility.