Dehydroepiandrosterone (DHEA) and synthetic DHEA analogs are modest inhibitors of HIV-1 IIIB replication.
Dehydroepiandrosterone (DHEA) and synthetic DHEA analogs are modest inhibitors of HIV-1 IIIB replication.
复制标题
脱氢表雄酮 (DHEA) 和合成 DHEA 类似物是 HIV-1 IIIB 复制的适度抑制剂。
DOI：
10.1089/aid.1992.8.625
复制
发表时间：
1992
影响因子：
1.5
通讯作者：
Schwartz,A
中科院分区：
文献类型：
--
作者：
Henderson,E;Yang,JY;Schwartz,A
研究表明，脱氢表雄酮（DHEA）可下调eb病毒（EBV）诱导的体外人淋巴细胞转化。脱氢表雄酮是一种由肾上腺分泌的天然类固醇。本文报道了脱氢表雄酮及其新型合成类似物16α-氟-5-雄酮-17-one（8354）和3β-羟基-16α-氟-5α-雄酮-17-one （OH8356）对人类免疫缺陷病毒（HIV-1）复制的影响。通过合胞体形成、p24抗原释放和逆转录酶活性积累测量，DHEA、8354或OH8356治疗可适度下调植物血凝素刺激的外周血淋巴细胞中HIV-1的复制。DHEA和8354也能减少hiv -1感染的SupT1淋巴细胞中合胞体的形成。脱氢表雄酮和脱氢表雄酮的合成类似物以前被证明具有抗增殖作用，现在被证明可以减少HIV-1的复制。脱氢表雄酮或脱氢表雄酮的合成类似物可为HIV-1感染提供替代和/或辅助治疗。
Down-regulation of Epstein-Barr virus (EBV) induced transformation of human lymphocytes in vitro by dehydroepiandrosterone (DHEA), a naturally occurring human steroid secreted by the adrenal gland has been demonstrated. This article reports on the effects of DHEA and its novel synthetic analogs 16α-fluoro-5-androsten-17-one (8354) and 3β-hydroxy-16α-fluoro-5α-androstan-17-one (OH8356) on human immunodeficiency virus (HIV-1) replication. Treatment with DHEA, 8354, or OH8356 resulted in a modest down-regulation of HIV-1 replication in phytohemagglutinin-stimulated peripheral blood lymphocytes as measured by syncytia formation, release of p24 antigen, and accumulation of reverse transcriptase activity. DHEA and 8354 also reduced syncytia formation in HIV-1-infected SupT1 lymphoblasts. DHEA and synthetic analogs of DHEA, which have been shown previously to have antiproliferative effects, now are shown to reduce HIV-1 replication. DHEA or synthetic analogs of DHEA could provide an alternative and/or adjuvant for HIV-1 infection.