Sleep and circadian rhythm disruption is corrected by lithium in a case of bipolar disorder with familial BRCA1 mutation.
Sleep and circadian rhythm disruption is corrected by lithium in a case of bipolar disorder with familial BRCA1 mutation.
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在患有家族性 BRCA1 突变的躁郁症患者中，锂可以纠正睡眠和昼夜节律紊乱。
DOI：
10.1111/bdi.13014
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发表时间：
2021
影响因子：
5.4
通讯作者：
McCarthy,MichaelJ
中科院分区：
文献类型：
--
作者：
Federoff,Monica;McCarthy,MichaelJ
双相情感障碍 (BD) 的特点是严重的情绪症状，通常伴有昼夜节律紊乱。临床前研究表明，锂作为 BD 的一线治疗药物，对昼夜节律有影响。 1 然而，人们很少关注锂对与昼夜节律紊乱相关的 BD 临床症状的影响。我们介绍了一名睡眠/觉醒活动严重中断的双相情感障碍患者的案例，并表明锂有效地纠正了她的昼夜节律紊乱。[摘自文章]双相情感障碍的版权是 Wiley-Blackwell 的财产，未经版权所有者明确书面许可，不得将其内容复制或通过电子邮件发送到多个网站或发布到列表服务器。但是，用户可以打印、下载或通过电子邮件发送文章供个人使用。本摘要可能会被删节。不保证副本的准确性。用户应参阅该材料的原始发布版本以获取完整摘要。版权适用于所有摘要。
Bipolar disorder (BD) is characterized by severe mood symptoms, often accompanied by circadian rhythm disturbances. Preclinical studies indicate that lithium, a first-line treatment for BD, has effects on circadian rhythms. 1 However, less attention has been given to the effects of lithium on the clinical symptoms of BD related to circadian rhythm disruption. We present a case of a BD patient with profound disruption in sleep/wake activity and show that lithium potently corrected her circadian rhythm disturbances.[Extracted from the article]Copyright of Bipolar Disorders is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.