TEAR FILM LIPID LAYER THICKNESS AS A FUNCTION OF BLINKING
TEAR FILM LIPID LAYER THICKNESS AS A FUNCTION OF BLINKING
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DOI：
10.1097/00003226-199407000-00012
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发表时间：
1994-07-01
期刊：
影响因子：
2.8
通讯作者：
GREINER, JV
中科院分区：
文献类型：
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作者：
KORB, DR;BARON, DF;GREINER, JV
使用定制设计的镜面反射监测系统研究了泪膜脂质层随眨眼的变化。根据特定的干涉色，对 104 名受试者在正常（“基线”）眨眼和“强力”眨眼条件下的泪膜脂质层进行了定量。研究发现，刻意、用力眨眼会显着增加泪膜的脂质层厚度（LLT）。发现增加的幅度与基线 LLT 值相关；基线 LLT 值为 75-150 nm 的个体在用力眨眼后 LLT 平均增加 33 nm，而基线 LLT 值小于或等于 60 nm 的受试者平均增加 19 nm。各组之间增加幅度的差异非常显着（p = 0.0001）。数据表明，除了在脂质跨泪膜扩散方面发挥作用之外，眨眼机制可能通过增加睑板腺脂质的表达而在维持脂质层方面发挥重要作用。
Alterations in the tear film lipid layer as a function of blinking were investigated using a custom-designed specular reflection monitoring system. The tear film lipid layer of 104 subjects under conditions of normal (''baseline'') blinking and ''forceful'' blinking was quantitated on the basis of specific interference colors. Deliberate, forceful blinking was found to significantly increase the lipid layer thickness (LLT) of the tear film. The magnitude of increase was found to be correlated with the baseline LLT values; individuals with baseline LLT values of 75-150 nm demonstrated a mean increase in LLT of 33 nm following forceful blinking, whereas subjects with baseline LLT values less-than-or-equal-to 60 nm experienced a mean increase of 19 nm. The difference in the magnitude of increase between the groups was highly significant (p = 0.0001). The data suggest that, in addition to playing a role in the spreading of lipid across the tear film, the blinking mechanism may be important in the maintenance of the lipid layer by augmenting the expression of lipids from the meibomian glands.