A GENERAL-ROUTE TO ALPHA,ALPHA-DIFLUOROKETONES
A GENERAL-ROUTE TO ALPHA,ALPHA-DIFLUOROKETONES
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DOI：
10.1016/s0040-4039(00)73671-9
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发表时间：
1993-05-14
影响因子：
1.8
通讯作者：
BURTON, DJ
中科院分区：
文献类型：
--
作者：
QIU, ZM;BURTON, DJ
以Pd(PPh_3)_4为催化剂，在无溶剂的条件下，室温下碘二氟甲基酮与烯烃的反应可得到较高的1：1加成产物。用锌/氯化镍2.6H2O/四氢呋喃处理加合物得到α，α-二氟酮。在反应条件下，烯烃中的各种官能团是可以容忍的，包括烷基、三甲基硅基、羟基、环氧基、羰基和酯基。
The reaction of iododifluoromethyl ketones with alkenes catalyzed by Pd(PPh3)4 in the absence of solvent at room temperature gives high yields of the corresponding 1:1 addition products. Treatment of the adducts with Zn/NiCl2.6H2O/THF affords alpha,alpha-difluoroketones. A variety of functional groups in the olefins are tolerated under the reaction conditions, including alkyl, trimethylsilyl, hydroxy, epoxy, carbonyl and ester groups.