Exercise training improves cardiovascular autonomic modulation in response to glucose ingestion in obese adults with and without type 2 diabetes mellitus.
Exercise training improves cardiovascular autonomic modulation in response to glucose ingestion in obese adults with and without type 2 diabetes mellitus.
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DOI：
10.1016/j.metabol.2009.10.011
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发表时间：
2010-06
影响因子：
9.8
通讯作者：
Kanaley, Jill A.
中科院分区：
文献类型：
--
作者：
Goulopoulou, Styliani;Baynard, Tracy;Franklin, Ruth M.;Fernhall, Bo;Carhart, Robert, Jr.;Weinstock, Ruth;Kanaley, Jill A.
本研究探讨了有氧运动训练对伴有和不伴有2型糖尿病（T2 D）的肥胖个体在口服葡萄糖负荷下对心率和收缩压调节的迷走神经和交感神经影响。在16周中等强度有氧运动训练之前和之后，在患有T2 D（T2 D组，n=23）和不患有T2 D（OB组，n=36）的肥胖受试者中，在12小时过夜禁食后以及对葡萄糖摄入（75 g葡萄糖）的反应中，测量逐搏动脉压和连续心电图。使用收缩压变异性（BPV）、心率变异性（HRV）的频谱分析和压力反射敏感性（BRS）的分析来评估自主神经调节。葡萄糖摄入可显著增加低频BPV（LFSBP）、低频HRV（LFRRI）和HRV低频成分与高频成分比值（LFRRI/HFRRI），降低高频功率（HFRRI）（p<0.05）。运动训练增加了两组对葡萄糖摄入的LFRRI和LFRRI/HFRRI反应，降低了HFRRI和LFSBP反应（p<0.05），但仅增加了OB组的空腹BRS（p<0.05）;葡萄糖摄入对BRS没有影响（p>0.05）。总之，16周的运动训练计划改善了肥胖成年人对口服葡萄糖负荷的心脏自主调节，与糖尿病状态无关，并且在体重，身体成分，健身水平和血糖控制方面没有显着变化。
This study examined the effect of aerobic exercise training on vagal and sympathetic influences on the modulations of heart rate and systolic blood pressure in response to an oral glucose load in obese individuals with and without type 2 diabetes (T2D). Beat-to-beat arterial pressure and continuous electrocardiogram were measured after a 12-hour overnight fast and in response to glucose ingestion (75 g dextrose) in obese subjects with (T2D group, n=23) and without (OB group, n=36) T2D, before and after 16 weeks of aerobic exercise training at moderate intensity. Autonomic modulation was assessed using spectral analysis of systolic blood pressure variability (BPV), heart rate variability (HRV), and analysis of baroreflex sensitivity (BRS). Glucose ingestion significantly increased low frequency BPV (LFSBP), low frequency HRV (LFRRI)) and the ratio of low-to-high frequency components of HRV (LFRRI/HFRRI), and decreased the high frequency power (HFRRI), (p<0.05). Exercise training increased LFRRI and LFRRI/HFRRI responses, and reduced HFRRI and LFSBP responses to glucose ingestion in both groups (p<0.05), but increased fasted BRS in the OB group only (p<0.05); glucose intake had no effect on BRS (p>0.05). In conclusion, a 16-week exercise training program improved cardiac autonomic modulation in response to an oral glucose load in obese adults, independently of diabetes status, and in the absence of remarkable changes in body weight, body composition, fitness level, and glycemic control.
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影响因子：
7.7
作者：
Loimaala, A;Huikuri, HV;Vuori, I
通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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Kanaley, Jill A.
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影响因子：
7.7
作者：
LAAKSO, M;EDELMAN, SV;BARON, AD
通讯作者：
BARON, AD
影响因子：
9.8
作者：
Baynard, T;Franklin, RM;Kanaley, JA
通讯作者：
Kanaley, JA