Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway
Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway
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DOI：
10.1038/sj.mp.4001998
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发表时间：
2007-09-01
影响因子：
11
通讯作者：
Hayward, N.
中科院分区：
文献类型：
--
作者：
Matigian, N.;Windus, L.;Hayward, N.
为了识别双相情感障碍（BD1）中失调的基因，我们使用全基因组微阵列进行了全局基因表达谱分析。为了最大限度地减少病例和对照组之间基因表达水平的遗传变异，我们比较了与该疾病不一致的同卵双生子的淋巴母细胞样细胞系的表达谱。我们鉴定了82个基因，在3个BD1病例中与他们的双胞胎相比差异表达>= 1.3倍，并且在统计学上（P
To identify genes dysregulated in bipolar disorder ( BD1), we carried out global gene expression profiling using whole-genome microarrays. To minimize genetic variation in gene expression levels between cases and controls, we compared expression profiles in lymphoblastoid cell lines from monozygotic twin pairs discordant for the disease. We identified 82 genes that were differentially expressed by >= 1.3-fold in three BD1 cases compared to their co-twins, and which were statistically ( P