Oncolytic Viral Therapy and the Immune System: A Double-Edged Sword Against Cancer.
Oncolytic Viral Therapy and the Immune System: A Double-Edged Sword Against Cancer.
复制标题
溶瘤病毒疗法和免疫系统：对抗癌症的双刃剑
DOI：
10.3389/fimmu.2018.00866
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发表时间：
2018
影响因子：
7.3
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Marelli G;Howells A;Lemoine NR;Wang Y
溶瘤病毒治疗是一种很有前途的抗肿瘤新策略。溶瘤病毒（OV）可以在癌细胞中复制，但不能在正常细胞中复制，导致肿瘤块溶解。除了这种主要作用外，OV还可以刺激免疫系统。肿瘤是一种免疫抑制环境，其中免疫系统被沉默以避免针对癌细胞的免疫应答。将OV递送到肿瘤中唤醒免疫系统，使得其可以促进针对肿瘤本身的强烈且持久的应答。先天性和适应性免疫应答都有助于这一过程，产生针对肿瘤抗原的免疫应答并促进免疫记忆。然而，病毒被免疫系统识别为病原体，因此抗病毒反应可能是OV的一大障碍。在这种新的情况下，找到抗肿瘤和抗病毒免疫之间的平衡是研究人员的优先事项。在这篇综述中，我们提供了一个概述的各种方式，免疫系统的不同组成部分可以与OV结盟。我们分析了不同的免疫反应，以突出新的和有前途的前景，导致抗肿瘤反应增加和免疫反应减少的OV。
Oncolytic viral therapy is a new promising strategy against cancer. Oncolytic viruses (OVs) can replicate in cancer cells but not in normal cells, leading to lysis of the tumor mass. Beside this primary effect, OVs can also stimulate the immune system. Tumors are an immuno-suppressive environment in which the immune system is silenced in order to avoid the immune response against cancer cells. The delivery of OVs into the tumor wakes up the immune system so that it can facilitate a strong and durable response against the tumor itself. Both innate and adaptive immune responses contribute to this process, producing an immune response against tumor antigens and facilitating immunological memory. However, viruses are recognized by the immune system as pathogens and the consequent anti-viral response could represent a big hurdle for OVs. Finding a balance between anti-tumor and anti-viral immunity is, under this new light, a priority for researchers. In this review, we provide an overview of the various ways in which different components of the immune system can be allied with OVs. We have analyzed the different immune responses in order to highlight the new and promising perspectives leading to increased anti-tumor response and decreased immune reaction to the OVs.
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DOI：
10.1038/mt.2011.276
发表时间：
2012-04
期刊：
Molecular therapy : the journal of the American Society of Gene Therapy
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.2
作者：
Ferguson MS;Lemoine NR;Wang Y
通讯作者：
Wang Y
影响因子：
11.1
作者：
Freedman JD;Hagel J;Scott EM;Psallidas I;Gupta A;Spiers L;Miller P;Kanellakis N;Ashfield R;Fisher KD;Duffy MR;Seymour LW
通讯作者：
Seymour LW
影响因子：
11.4
作者：
Duell, J.;Dittrich, M.;Topp, M. S.
通讯作者：
Topp, M. S.
影响因子：
45.3
作者：
Barve, Minal;Bender, James;Nemunaitis, John J.
通讯作者：
Nemunaitis, John J.