Targeting Autophagy for Oncolytic Immunotherapy.
Targeting Autophagy for Oncolytic Immunotherapy.
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靶向自噬的溶瘤免疫治疗
DOI：
10.3390/biomedicines5010005
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发表时间：
2017-01-11
期刊：
影响因子：
4.7
通讯作者：
Meng S
中科院分区：
文献类型：
--
作者：
Hu L;Jiang K;Ding C;Meng S
溶瘤病毒（OV）能够通过多种机制发挥抗癌作用，包括免疫介导的肿瘤细胞死亡，凸显了它们在免疫治疗中的潜在用途。自噬等多种适应机制有助于 OV 介导的抗肿瘤特性。自噬在癌症治疗过程中调节免疫原性信号传导，可用于设计治疗组合，使用诱导或阻断自噬的方法来增强 OV 的治疗功效。在本文中，我们回顾了自噬、癌症、免疫和 OV 之间复杂的相互作用，总结了 OV 扰动的自噬对溶瘤免疫的贡献的最新进展，并讨论了靶向自噬以增强溶瘤免疫治疗的挑战。
Oncolytic viruses (OVs) are capable of exerting anti-cancer effects by a variety of mechanisms, including immune-mediated tumor cell death, highlighting their potential use in immunotherapy. Several adaptation mechanisms such as autophagy contribute to OV-mediated anti-tumor properties. Autophagy regulates immunogenic signaling during cancer therapy which can be utilized to design therapeutic combinations using approaches that either induce or block autophagy to potentiate the therapeutic efficacy of OVs. In this article, we review the complicated interplay between autophagy, cancer, immunity, and OV, summarize recent progress in the contribution of OV-perturbed autophagy to oncolytic immunity, and discuss the challenges in targeting autophagy to enhance oncolytic immunotherapy.