Potential role of group X secretory phospholipase A2 in cyclooxygenase-2-dependent PGE2 formation during colon tumorigenesis
Potential role of group X secretory phospholipase A2 in cyclooxygenase-2-dependent PGE2 formation during colon tumorigenesis
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DOI：
10.1016/s0014-5793(00)02350-4
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发表时间：
2000-12-29
期刊：
影响因子：
3.5
通讯作者：
Hanasaki, K
中科院分区：
文献类型：
--
作者：
Morioka, Y;Ikeda, M;Hanasaki, K
Although the cyclooxygenase-2 (COX-2) pathway of the arachidonic acid cascade has been suggested to play an important role in colon carcinogenesis, there is little information concerning the identity of phospholipase A(2) (PLA(2)) involved in the arachidonic acid release in colon tumors, Here, me compared the potencies of three types of secretory PLA(2)s (group TB, IIA and X sPLA(2)s) for the arachidonic acid release from cultured human colon adenocarcinoma cells, and found that group X sPLA(2) has the most powerful potency in the release of arachidonic acid leading to COX-2-dependent prostaglandin E-2 (PGE(2)) formation. Furthermore, immunohistological analysis revealed the elevated expression of group X sPLA(2) in human colon adenocarcinoma neoplastic cells in concert With augmented expression of COX-2, These findings suggest a critical role of group X sPLA(2) in the PGE(2) biosynthesis during colon tumorigenesis. (C) 2000 Federation of European Biochemical Societies, Published by Elsevier Science B.V. All rights reserved.
