Food groups and renal cell carcinoma: A case-control study from Italy
Food groups and renal cell carcinoma: A case-control study from Italy
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DOI：
10.1002/ijc.22225
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发表时间：
2007-02-01
影响因子：
6.4
通讯作者：
La Vecchia, Carlo
中科院分区：
文献类型：
--
作者：
Bravi, Francesca;Bosetti, Cristina;La Vecchia, Carlo
尽管营养和饮食与肾细胞癌（RCC）有关，但特定食物或营养素对这种癌症的作用仍然存在争议。我们在一项意大利病例对照研究中评估了多种食物与肾细胞癌风险之间的关系，该研究包括 767 名年龄小于 79 岁且经组织学证实的肾细胞癌患者（494 名男性和 273 名女性），以及 1,534 名对照者（988 名男性和 546 名女性），这些对照者因与长期饮食调整无关的各种急性非肿瘤性疾病病例入住同一家医院。一份经过验证且可重复的食物频率调查问卷，包括 78 种食物和饮料，以及关于饮酒的单独部分，用于评估患者在诊断或入院前 2 年的饮食习惯。考虑能量摄入和其他主要混杂因素后获得多变量比值比 (OR)。面包的风险存在显着的直接趋势（最高摄入量与最低摄入量五分之一的 OR = 1.94），意大利面和米饭（OR = 1.29）以及牛奶和酸奶（OR = 1.27）的风险适度过高。家禽（OR = 0.74）、加工肉类（OR = 0.64）和蔬菜（OR = 0.65）与肾细胞癌风险呈负相关。咖啡和茶、汤、鸡蛋、红肉、鱼、奶酪、豆类、土豆、水果、甜点和糖之间没有发现任何关系。这项研究的结果进一步表明了 RCC 的饮食相关性，特别表明富含精制谷物和缺乏蔬菜的饮食可能对 RCC 产生不利作用。 (c) 2006 年威利-利斯。公司
Although nutrition and diet have been related to renal cell carcinoma (RCC), the role of specific foods or nutrients on this cancer is still controversial. We evaluated the relation between a wide range of foods and the risk of RCC in an Italian case-control study including 767 patients (494 men and 273 women) younger than 79 Years with incident, histologically confirmed RCC, and 1,534 controls (988 men and 546 women) admitted to the same hospitals as cases for a wide spectrum of acute, non-neoplastic conditions, not related to long term diet modifications. A validated and reproducible food frequency questionnaire, including 78 foods and beverages, plus a separate section on alcohol drinking, was used to assess patients' dietary habits 2 years before diagnosis or hospital admission. Multivariate odds ratios (OR) were obtained after allowance for energy intake and other major confounding factors. A significant direct trend in risk was found for bread (OR = 1.94 for the highest versus the lowest intake quintile), and a modest excess of risk was observed for pasta and rice (OR = 1.29), and milk and yoghurt (OR = 1.27). Poultry (OR = 0.74), processed meat (OR = 0.64) and vegetables (OR = 0.65) were inversely associated with RCC risk. No relation was found for coffee and tea, soups, eggs, red meat, fish, cheese, pulses, potatoes, fruits, desserts and sugars. The results of this study provide further indications on dietary correlates of RCC, and in particular indicate that a diet rich in refined cereals and poor in vegetables may have an unfavorable role on RCC. (c) 2006 Wiley-Liss. Inc.