Facile acylation of glycerophosphocholine catalyzed by trifluoroacetic anhydride.
Facile acylation of glycerophosphocholine catalyzed by trifluoroacetic anhydride.
复制标题
三氟乙酸酐催化甘油磷酸胆碱的轻松酰化。
作者：
P. Kanda;M. Wells
本文介绍了一种合成短链磷脂酰胆碱的简化方法。用混合脂肪酸-三氟乙酸酐对溶解于三氟乙酸甘油-3-磷酸胆碱(GPC)进行酰化反应。使用1.5至2.0当量的混合酸酐，GPC羟基，在30分钟的反应时间内，产率可达到70%以上。这允许更经济地使用标记的短链酸。
A simplified procedure for the synthesis of short acyl chain phosphatidylcholines is described. A mixed fatty acid-trifluoroacetic anhydride is used to acylate sn-glycero-3-phosphocholine (GPC) which has been dissolved in trifluoroacetic acid. Yields exceeding 70% are achieved in 30-min reaction time using 1.5 to 2.0 equivalents of mixed anhydride per, GPC hydroxyl. This allows a more economical use of labeled short chain acids.