Cancer-specific beliefs and survival: a population-based study of African-American and White breast cancer patients.
Cancer-specific beliefs and survival: a population-based study of African-American and White breast cancer patients.
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癌症特异性信念和生存：针对非裔美国人和白人乳腺癌患者的一项基于人群的研究。
DOI：
10.1007/s10552-004-2232-4
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Jones,BethA
中科院分区：
文献类型：
--
作者：
Soler-Vila,Hosanna;Kasl,StanislavV;Jones,BethA
目的：人们对癌症及其治疗的看法已被证明会影响诊断时的癌症分期，从而影响预后。这些信仰和生存之间的关联研究不足，特别是在种族/民族多样化的人口。我们调查了癌症特异性信念和生存率之间的关系，在一个队列的非洲裔美国人和白色妇女新诊断的乳腺癌随访长达15 years.Methods：我们研究了信念，癌症的检测，治疗和可治愈性，在人口为基础的队列的145名非洲裔美国人和177名白色妇女诊断为乳腺癌在康涅狄格州，美国，在1987年和1989年之间。考克斯比例风险模型进行了调整，在诊断阶段，其他生物医学变量，社会人口和生活方式factors.Results：在多变量模型中，感知癌症不可治愈性与任何原因死亡的风险较高（风险比（HR）=1.67，95置信区间（CI）=1.11，2.51）。进一步控制肿瘤特征，遗传改变，获得护理和其他心理社会因素并没有改变这些结果。其他癌症的具体信念检查这里没有相关survival.Conclusions：感知癌症的不可治愈性是独立相关的乳腺癌患者在完全调整模型中的生存。这种关联的潜在机制的识别有可能转化为癌症患者的干预策略。
Objective: Beliefs about cancer and its treatment have been shown to influence cancer stage at diagnosis and, thus, prognosis. The association between these beliefs and survival is understudied, especially among racially/ethnically diverse populations. We investigated the relationship between cancer-specific beliefs and survival in a cohort of African-American and White women with newly diagnosed breast cancer followed for up to 15 years.Methods: We examined beliefs about cancer detection, treatment, and curability in a population-based cohort of 145 African-American and 177 White women diagnosed with breast cancer in Connecticut, US, between 1987 and 1989. Cox proportional-hazards models were adjusted for stage at diagnosis, other biomedical variables, socio-demographic and lifestyle factors.Results: In multivariate models, perceived cancer incurability was associated with a higher risk of death from any cause (hazards ratio (HR)=1.67, 95 confidence interval (CI)=1.11, 2.51). Further control for tumor characteristics, genetic alterations, access to care, and additional psychosocial factors did not alter these findings. Other cancer-specific beliefs examined here were not related to survival.Conclusions: Perceived cancer incurability is independently associated with survival among breast cancer patients in fully adjusted models. The identification of the underlying mechanisms of this association has potential for translation into intervention strategies for cancer patients.