Decreased VDR expression in cutaneous melanomas as marker of tumor progression: new data and analyses.
Decreased VDR expression in cutaneous melanomas as marker of tumor progression: new data and analyses.
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发表时间：
2014-06
影响因子：
2
通讯作者：
A. Brożyna;W. Jóźwicki;A. Slominski
中科院分区：
文献类型：
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作者：
A. Brożyna;W. Jóźwicki;A. Slominski
维生素D3通过维生素D受体（VDR）起作用，影响广泛的生物活性，包括抑制增殖和血管生成，具有净抗肿瘤作用。VDR表达在许多肿瘤中受到干扰，包括黑色素瘤。目的探讨维生素D受体（VDR）在黑色素瘤中的表达及其与预后的关系。材料与方法采用免疫组化法分析69例皮肤黑色素瘤VDR与预后因素的关系。结果：低进展期黑色素瘤VDR表达明显高于进展期黑色素瘤。其他标志物的存在，如溃疡和缺乏或非活跃的肿瘤浸润淋巴细胞（TIL）伴随着显着较低的VDR表达。VDR表达也影响总生存期（OS），在无溃疡的病例中效果最明显。结论VDR高表达决定了肿瘤恶性程度低，预后好。VDR表达的缺失影响黑色素瘤的肿瘤行为，允许疾病进展。VDR表达还可以作为常规组织病理学评估中的预后标志物。
BACKGROUND Vitamin D3, acting via vitamin D receptor (VDR) affects a wide range of biological activities, including inhibition of proliferation and angiogenesis, with net antitumor effects. VDR expression is disturbed in many tumors, including melanomas. AIM To find correlation between VDR expression in melanomas and prognostic biomarkers. MATERIALS AND METHODS VDR was analyzed immunohistochemically in 69 cutaneous melanomas in relation to prognostic factors. RESULTS Less advanced melanomas showed significantly higher VDR expression than the advanced stages. The presence of other markers such as ulceration and lack or non-brisk tumor infiltrating lymphocytes (TILs) was accompanied by significantly lower VDR expression. VDR expression also affected overall survival (OS) with most noticeable effect in the cases without ulceration. CONCLUSION High VDR expression determines a less malignant phenotype and is related to better prognosis. Loss of VDR expression affects melanoma tumor behavior, allowing for progression of disease. VDR expression can also serve as a prognostic marker in routine histopathology evaluation.