Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores
Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores
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DOI：
10.1002/anie.201814370
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发表时间：
2019-04-01
影响因子：
16.6
通讯作者：
Armstrong, Fraser A.
中科院分区：
文献类型：
--
作者：
Megarity, Clare F.;Siritanaratkul, Bhavin;Armstrong, Fraser A.
在活细胞中，氧化还原链依赖于使用微小外壳（如线粒体基质或叶绿体基质）的纳米限制，以浓缩酶并限制烟酰胺辅因子和其他代谢物必须扩散的距离。在利用这一原理的化学类似物中，烟酰胺腺嘌呤二核苷酸磷酸（NADPH）和NADP（+）在铁氧还蛋白-NADP（+）还原酶和第二种酶之间快速循环-这对酶在氧化铟锡电极的5-100 nm尺度孔内并列。所得到的电极材料，表示为（FNR+E2）@ITO/载体，可以驱动和利用潜在的大量酶催化反应。
In living cells, redox chains rely on nanoconfinement using tiny enclosures, such as the mitochondrial matrix or chloroplast stroma, to concentrate enzymes and limit distances that nicotinamide cofactors and other metabolites must diffuse. In a chemical analogue exploiting this principle, nicotinamide adenine dinucleotide phosphate (NADPH) and NADP(+) are cycled rapidly between ferredoxin-NADP(+) reductase and a second enzyme-the pairs being juxtaposed within the 5-100 nm scale pores of an indium tin oxide electrode. The resulting electrode material, denoted (FNR+E2)@ITO/support, can drive and exploit a potentially large number of enzyme-catalysed reactions.